Research Article
High Expressions of Notch and Survivin in Elderly Patients with Glioma Contribute to an Unfavorable Prognosis
Figure 2
Alternation of the Notch pathway affects Survivin expression in glioma cells. The mRNA expression of Survivin was determined by qRT-PCR in the cultured U251 cells treated with 10 μM γ-secretase inhibitor (GSI) MRK-003 for 48 h to block the Notch signaling pathway (a) and stimulated with 10 μg/mL Jagged1 to activate the Notch signaling pathway (b). (c) The delivery of pN3-N1ICD in combination with Survivin promoter into U251 cells yielded a 2.4-fold increase in Survivin promoter activity. # indicates compared with the corresponding control.
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