Evaluation of a Modified Flow-Through Method for Predictive Dissolution and In Vitro/In Vivo Correlations of Immediate Release and Extended Release Formulations

Figure 4

Profile comparison and IVIVC analysis of the in vitro percent drug dissolved () versus the in vivo percent drug absorbed () of paracetamol IR tablets. (a) In vitro dissolved and in vivo absorbed profiles for paracetamol reference tablet; (b) in vitro dissolved and in vivo absorbed profiles for paracetamol test 1 tablet; (c) in vitro dissolved and in vivo absorbed profiles for paracetamol test 3 tablet; linear regression plots of mean versus mean obtained from modified flow-through method (d) and QC method (e). All in vitro () and in vivo () data are the .

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