Evaluation of a Modified Flow-Through Method for Predictive Dissolution and In Vitro/In Vivo Correlations of Immediate Release and Extended Release Formulations

Table 1

Mathematical models and release/absorption kinetics parameters comparisons for paracetamol IR tablets and felodipine ER tablets.

Formulations		Dissolution/deconvolution methods	Dissolution models	Model parameters			MSC
Paracetamol IR tablets
In vitro dissolved	Reference	QC method	Weibull			0.8678	1.52
		Modified flow-through method				0.9976	5.79
	Test 1	QC method				0.9756	3.21
		Modified flow-through method				0.999	6.61
	Test 2	QC method				0.9129	1.94
		Modified flow-through method				0.9997	7.85
	Test 3	QC method				0.9083	1.89
		Modified flow-through method				0.9999	8.62
	Test 4	QC method				0.9579	2.67
		Modified flow-through method				0.9986	6.24
In vivo absorbed	Reference	Wagner-Nelson method				0.9986	5.75
	Test 1	Wagner-Nelson method				0.9959	4.69
	Test 2	Wagner-Nelson method				0.9374	1.97
Felodipine ER tablets
In vitro dissolved	Reference	QC method	Zero-order			0.9857	3.99
		Modified flow-through method				0.9729	3.48
	Test 1	QC method				0.996	5.28
		Modified flow-through method				0.9939	4.98
	Test 2	QC method				0.9809	3.71
		Modified flow-through method				0.9307	2.54
	Test 3	QC method				0.9929	4.69
		Modified flow-through method				0.9526	2.92
In vivo absorbed	Reference	Loo-Riegelman method				0.9814	3.7
	Test 1	Loo-Riegelman method				0.9914	4.48

is the fraction (%) of drug released at time ; Td is the mean dissolution time, when 63.2% of the drug in the dosage form has been released; is the shape parameter; is the zero-order release constant.