miR-598 Represses Cell Migration and Invasion of Non-Small-Cell Lung Cancer by Inhibiting MSI2

Figure 4

MSI2 is the target gene of miR-598: (a) sequence alignment of miR-598 and its conserved target site in RTKN-3-UTR, predicted in the ENCORI database (http://starbase.sysu.edu.cn/); (b) relative luciferase activity in 293FT cells cotransfected with pGL3-MSI2-wt or pGL3-MSI2-mut reporter plasmids containing miR-598 potential binding sites or control plasmids; (c) the MSI2 mRNA expression level in A549 cells upon miR-598 mimic transfection. a indicates compared with miR-NC.

(a)

(b)

(c)