Theranostic Effect of Folic Acid Functionalized MIL-100(Fe) for Delivery of Prodigiosin and Simultaneous Tracking-Combating Breast Cancer

Figure 5

The selective index (SI) values of MIL-100(Fe)@PG and MIL-100 (Fe)/FA@PG were compared with free PG against (a) MCF-7 and (b) normal skin fibroblast cells after 8, 24, and 48 h exposure. Free prodigiosin was kept at an equal concentration with drug-loaded MOFs. All mentioned data are displayed as the (). The statistical evaluation of IC50 was compared pairwise between IC50 of each treating time and maximum concentration of the drug used as a control ( for normal fibroblast and for MCF-7 was considered as untreated cells), using -test with ( value ≤ 0.05), ( value ≤ 0.01), ( value ≤ 0.001), ( value ≤ 0.0001) significance values.

(a)

(b)