Review Article

Nanomaterials: A Promising Therapeutic Approach for Cardiovascular Diseases

Table 4

Tabulated literature citing carbon nanomaterials for cardiovascular diseases, where n.m. is not mentioned.

Type of carbon nanomaterialName of polymerIn vivo studiesElectrical interpretationSizeBiological interpretationReferences

Carbon quantum dots (CQD)Poly glycerol sebacate; polycaprolactonen.m.The presence of QD, increased electrical conductivity nm1% CQD, decreased cell viability; 0.5%CQD, persisted cell viability[149]
Carbon nanotubes (CNT)Polyurethane, chitosanH9C2 cellsIncrease in electrical conductivityn.m.Biocompatible with H9C2 cells[150]
p-Phenylenediamine surface-functionalized CQDSilk fibroin/polylactic acidRat cardiomyocytesImproved electrical conductivity among cardiomyocytesn.m.Increased cardiac marker gene expression[151]
Carbon nanotubes (CNT)Polyvinyl alcohol, chitosanRat mesenchymal stem cellsThe presence of large quantities of CNT, decreased electrical conductivity to  nmExpression of Nkx2.5, Troponin I, and β–MHC cardiac marker increased significantly[152]
Carbon nanotubes (CNT)Gelatin with methacrylate anhydrideNeonatal rat ventricular myocytesShowed apparent spontaneous electrical conductivity; Beta1-integrin pathway was involved in modulation of electrical impulsesn.m.Increase in expression of p-FAK and RhoA in cardiac constructs[153]
SWCNTsGelatinRat H9c2 cellsn.m.n.m.Increased expression, proliferation, and differentiation[154]
MWCNTs functionalized with carbodihydraziden.m.HL-1 cardiomyocytesThe electrical conductivity of the scaffold was 0.015 S/cm166 nmImproved heartbeat and cellular viability[155]
MWCNTsPCLRat H9c2 cellsConductivity increased with PCL contentn.m.Myoblast cells showed adherence for 4 days[156]