A Potential Notion on Alzheimer’s Disease: Nanotechnology as an Alternative Solution

Figure 2

The major pathological characteristics of Alzheimer’s disease. Accumulation of amyloid beta, neurofibrillary tangles persuaded by hyper phosphorylated tau protein and neuronal apoptosis. Amyloid beta is produced from amyloid beta precursor protein splitted by beta secretase and gamma secretase. AB monomer accumulates to produce oligomers of various molecular weight and then fibriller AB. These forms plaques in the brains of AD patients. Excessive accumulation, tau hyperphosphorylation, and neuronal apoptosis initiate series of pathological alterations including cognitive deficits and brain atrophy.