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Journal of Nutrition and Metabolism
Volume 2010, Article ID 340570, 4 pages
Clinical Study

Insulin Therapy and Body Weight, Body Composition and Muscular Strength in Patients with Type 2 Diabetes Mellitus

1UMR 5536 CNRS/Université de Bordeaux 2(Victor Segalen), 33000 Bordeaux, France
2Service de Nutrition-Diabétologie, Hôpital Haut-Lévêque, Avenue de Magellan, 33600 Pessac, France

Received 22 May 2009; Accepted 2 August 2009

Academic Editor: Hans P. Sauerwein

Copyright © 2010 H. Gin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims. To determine the progression of body weight (BW) and body composition (BC) in patients with type 2 diabetes mellitus (T2D) on insulin therapy and the consequences on muscle strength (MS) as a reflect of free fat mass increases. Research design and methods. We analysed BC using air displacement plethysmography and MS by hand grip dynamometry in 40 T2D before and after three (M3) and six months (M6) of insulin therapy. Results. at baseline HbA1c was 9.76 1.6% and BW was stable with fat mass (FM) 28 10.7 kg; and fat free mass (FFM) 52.4 11 kg; at M6, HbA1c improved to 7.56 0.8%; insulin doses tended to increase. BW gain at M6 was 3.2 4.2 kg and with an increase of only 25% by M3; it was composed of FM, whereas FFM was unchanged. MS did not increase on insulin therapy. Conclusions. In T2D, BW gain was composed exclusively of FM with no improvement in MS.