Insulin Therapy and Body Weight, Body Composition and Muscular Strength in Patients with Type 2 Diabetes Mellitus

Table 1

Evolution from M0 to M6 of body parameters and Hb1Ac levels during insulin therapy in patients with type 2 diabetes mellitus. Results are mean (SD), 𝑃 indicates the significance of the difference versus the baseline value (NS: nonsignificant).

	3 months (M3)	6 months (M6)
Weight change (kg)	+ 0.7 (2.3)	+ 3.1 (2.2) 𝑃<.008
Fat mass change (kg)	− 0 .2 (3.1)	+ 3.1 (2.7) 𝑃<.012
Waist circumference change (cm)	−0.3 (3.8)	+ 1.7 (4.5) 𝑃<.004
Fat free mass change (kg)	+ 0.9 (2.9) 𝑃=.15 (NS)	− 0.1 (2.6) 𝑃=.82 (NS)
Muscle strength change (kg)	+ 0.4 (2.9) 𝑃=0.57	+ 0.4 (4.2) 𝑃=.87
HbA1c change (%)	− 2.4 (1.7) 𝑃<0.0005	− 2.2 (1.7) 𝑃<.0005
Insulin doses (U/kg)	0.41 (0.32)	0.44 (0.27)