Differential Expression of Intestinal Genes in Opossums with High and Low Responses to Dietary Cholesterol
Table 2
Expression of intestinal genes in high and low responders fed the basal or HCLF diet.
Basal diet
HCLF diet
Gene
High responders
Low responders
High responders
Low responders
CD36 §
0.83 ± 0.12
0.80 ± 0.12
0.79 ± 0.12*
1.11 ± 0.31
SR-BI
0.81 ± 0.22
0.99 ± 0.35
0.77 ± 0.21*
1.19 ± 0.35
NPC1L1
1.18 ± 0.20
1.15 ± 0.15
1.08 ± 0.15
0.97 ± 0.04
ABCG5
0.55 ± 0.12†
0.48 ± 0.08†
1.20 ± 0.23
1.18 ± 0.27
ABCG8
0.55 ± 0.18†
0.41 ± 0.10†
1.21 ± 0.15
1.02 ± 0.26
ABCA1
0.48 ± 0.18†
0.47 ± 0.24†
1.34 ± 0.32
0.93 ± 0.25
HMGCR
1.33 ± 0.67
1.25 ± 0.25
0.88 ± 0.17
1.07 ± 0.21
HMGCS1
0.75 ± 0.26††
1.09 ± 0.44
0.38 ± 0.07*
0.80 ± 0.16
SQLE
1.01 ± 0.31††
1.27 ± 0.28††
0.15 ± 0.06*
0.46 ± 0.19
ACAT2
0.94 ± 0.18
0.71 ± 0.12
0.85 ± 0.10
1.05 ± 0.10
MTP
1.01 ± 0.10
1.04 ± 0.17
0.97 ± 0.13
1.18 ± 0.08
PLA2
1.22 ± 0.41
1.08 ± 0.53
1.31 ± 0.16**
0.88 ± 0.04
PLB
0.52 ± 0.49†
0.39 ± 0.15†
2.61 ± 1.23**
0.86 ± 0.21
IBABP
0.01 ± 0.01
0.02 ± 0.02
0.96 ± 1.29
0.11 ± 0.13
GAPDH §§
672 ± 90
740 ± 85
795 ± 152
686 ± 139
expression was normalized to GAPDH mRNA expression. §§Values of GAPDH mRNA expression. *Significant lower expression () in high responders versus low responders on HCLF diet. **Significant higher expression () in high responders versus low responders on HCLF diet. †Significant lower expression () on basal diet versus HCLF diet. ††Significant higher expression () on basal diet versus HCLF diet.
