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Journal of Nutrition and Metabolism
Volume 2010, Article ID 674240, 6 pages
Research Article

Vitamin D Status Is Not Associated with Outcomes of Experimentally-Induced Muscle Weakness and Pain in Young, Healthy Volunteers

1Department of Nutrition and Exercise Physiology, 217 Gwynn Hall, University of Missouri-Columbia, Columbia, MO 65211, USA
2Physical Therapy Department, 106 Lewis Hall, University of Missouri-Columbia, Columbia, MO 65211, USA

Received 3 August 2010; Revised 18 October 2010; Accepted 12 November 2010

Academic Editor: Tai C. Chen

Copyright © 2010 Susan M. Ring et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Vitamin D receptors have been identified in skeletal muscle; and symptoms of vitamin D deficiency include muscle weakness and pain. Moreover, increased serum 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with improved muscle function. To further clarify the importance of vitamin D to muscle, we examined the association between vitamin D status and exercise-induced muscle pain and weakness in healthy people. Muscle damage to the elbow flexors was induced with eccentric exercise (EE) in 48 individuals (22.5 ± 3.2 yrs). Muscle pain ratings following unloaded movement and peak isometric force (IF) were collected before EE and for 4 days post-EE. Linear regression was used to determine if serum 25(OH)D was a predictor of any outcome. In males, -values from 0.48 to 1.00. for IF ranged from 0 to 0.02 and -values from 0.48 to 1.00. In females, for pain ratings ranged from 0.01 to 0.11 and -values from 0.14 to 0.59. for IF ranged from 0 to 0.04 and -values from 0.41 to 0.90. In conclusion, vitamin D status did not predict muscle pain or strength after EE-induced muscle damage in young healthy men and women.