Relationship between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in Duodenal Biopsies, Serum Lipoproteins, and Dietary Fat in Colectomized Familial Adenomatous Polyposis Patients

Table 1

Baseline characteristics and fecal composition of fatty acids in colectomized patients with familial adenomatous polyposis. Results are presented as median and 25 and 75 percentiles.

Variables	Ileostomy (𝑛=12)	IPAA (𝑛=17)	P value
Age, year	51 (36, 70)	36 (24, 61)	.001
Age at colectomy, year	28 (19, 48)	21 (10, 45)	.07
Body mass index, kg/m^2	26.6 (19.8, 35.2)	25.5 (17.2, 30.8)	.4
Dietary total fat (% of energy)	31 (27, 37)	30 (29, 36)	.8
SAT	13 (11, 14)	11 (10, 13)	.3
MUFA	10 (9, 12)	10 (9, 11)	.5
PUFA	6 (5, 9)	7 (6, 9)	.3
Total-cholesterol (mmol/L)	4.9 (4.2, 6.0)	4.7 (3.9, 5.6)	.5
HDL-cholesterol (mmol/L)	1.8 (1.4, 2.1)	1.5 (1.3, 1.8)	.1
LDL-cholesterol (mmol/L)	2.8 (2.4, 3.8)	3.3 (2.1, 3.9)	.9
Triglycerides (mmol/L)	1.2 (0.9, 1.5)	1.0 (0.6, 1.5)	.3
Fatty acids in feces (weight %):
Myristic acid	1.4 (0.9, 3.9)	1.1 (0.6, 1.4)	.1
Palmitic acid	29.7 (26.1, 36.3)	32.7 (19.4, 38.4)	.7
Palmitolic acid	1.1 (0.5, 1.5)	0.5 (0.3, 0.7)	.003
Stearic acid	21.2 (13.8, 25.8)	28.1 (14.6, 36.5)	.2
Oleic acid	18.9 (16.6, 31.4)	17.7 (12.6, 37.9)	.9
Linoleic acid	16.7 (13.0, 25.3)	14.7 (10.7, 23.0)	.4
Alpha-linolenic acid	1.6 (0.6, 2.8)	0.7 (0.2, 1.3)	.04
Arachidonic acid	0.9 (0.4, 1.5)	0.2 (0.1, 0.8)	.04
COX mRNA expression in duodenal biopsies
COX-1	0.86 (0.74, 0.95)	0.92 (0.83, 1.00)	.1
COX- 2	1.11 (0.9, 1.25)	1.02 (0.96, 1.22)	.6

The values for eicosenoic acid and eicosadienoic acid are not shown, since these values were close to zero.
COX: cyclooxygenase; IPAA: ileal-pouch-anal anastomosis; MUFA: monounsaturated fatty acids; PUFA: polyunsaturated fatty acids; SAT: saturated fatty acids.