Opposing Effects of Omega-3 and Omega-6 Long Chain Polyunsaturated Fatty Acids on the Expression of Lipogenic Genes in Omental and Retroperitoneal Adipose Depots in the Rat

Table 5

Summary of the relationships between expression of SREPB1c mRNA in omental and perineal fat and AA, total n-6 PUFA, EPA, DPA, DHA, and total n-3 LCPUFA consent of erythrocyte phospholipids as a % of total fatty acids.

	SREBP1c omental fat	SREBP1c retroperitoneal fat
DHA	ns	ns
EPA	𝑟^2 = 0.62, 𝑃<.0001	𝑟^2 = 0.22, 𝑃<.005
DPA	𝑟^2 = 0.59, 𝑃<.0001	𝑟^2 = 0.19, 𝑃<.005
Total omega-3 LCPUFA	𝑟^2 = 0.59, 𝑃<.0001	𝑟^2 = 0.19, 𝑃<.005
AA	𝑟^2 = 0.66, 𝑃<.0001	𝑟^2 = 0.21, 𝑃<.005
Total n-6	𝑟^2 = 0.71, 𝑃<.0001	𝑟^2 = 0.20, 𝑃<.005

All relationships were determined by simple linear regression. Relationships between SREBP-1c mRNA expression and DPA, EPA and total omega-3 LCPUFA were all negative, whilst relationships with AA and total n-6 PUFA and SREBP-1c mRNA were positive.