The Relation of Coffee Consumption to Serum Uric Acid in Japanese Men and Women Aged 49–76 Years

Table 3

Serum concentrations of uric acid according to coffee intake in men and women.

Coffee (cups/d)	No. of subjects	Age-adjusted mean (95% CI)	Multivariate-adjusted mean (95% CI)*
Men
0	846	5.92 (5.84–6.01)	5.96 (5.88–6.04)
<1	1294	5.91 (5.84–5.98)	5.87 (5.81–5.94)
1–3	2216	5.85 (5.79–5.90)	5.83 (5.79–5.88)
4–6	508	5.72 (5.61–5.83)	5.79 (5.68–5.89)
≥7	100	5.55 (5.31–5.80)	5.69 (5.47–5.92)
Trend^†		P =.0003	P =.0016
Women
0	1054	4.55 (4.49–4.61)	4.58 (4.52–4.64)
<1	1810	4.61 (4.56–4.65)	4.61 (4.57–4.66)
1–3	3270	4.57 (4.54–4.61)	4.57 (4.54–4.60)
4–6	496	4.54 (4.45–4.63)	4.48 (4.39–4.56)
≥7	68	4.63 (4.40–4.87)	4.54 (4.32–4.76)
Trend^†		P =.94	P =.05

CI: confidence interval.
*Adjusted for age (continuous), BMI (continuous), smoking (never, past, <20, or ≥20 cigarettes/d), alcohol use (never, past, <30, 30–59, or ≥60 mL/d), work-related physical activity and leisure-time physical activity (each categorized at quartiles), hypertension, diabetes, eGFR (<60, 60–89, or ≥90 mL/minute/1.73 m²), and seafood intake (quartiles of daily intake for each sex).
^†P values were derived from multiple linear regression analysis with ordinal values assigned to categories of coffee consumption.