Hepatic Gene Expression Profiles Are Altered by Dietary Unsalted Korean Fermented Soybean (Chongkukjang) Consumption in Mice with Diet-Induced Obesity

Table 4

The numbers of genes differentially expressed in HDcon Mice but normalized or reversed by Chongkukjang consumption (HDC)⁽¹⁾.

Molecular function	Increase	Decrease	Total
Metabolism	19	34	53
Defense/stress/inflammation responses	0	13	13
Signal transduction/apoptosis/cell cycle	66	31	97
Transcription regulation	28	22	50
Protein synthesis and modification	24	19	43
Transport	23	20	43
Cellular adhesion/cytoskeleton/trafficking	11	5	16
Chromosome remodeling	14	6	20
DNA replication	5	4	9
RNA processing	10	2	12
Microtubule-based movement	7	4	11
Unclassified	13	15	28
Total	220	175	395

⁽¹⁾Data represent a summary of results of six independent hybridizations. In three of six replicated experiments, the labeling of HDcon and NDcon samples was reversed to compensate for any nonlinearity in the emission signal intensity response curve for each fluorophore. Genes designated as differentially expressed in the HDcon mice were those for which the normalized signal increased or decreased at least 2.0-fold and detected as significant change by SAM method.