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Journal of Nutrition and Metabolism
Volume 2011, Article ID 647514, 17 pages
Review Article

T2DM: Why Epigenetics?

INSERM U986, Bicêtre Hospital, University of Paris-Sud, Le Kremlin-Bicêtre, France

Received 11 August 2011; Accepted 20 September 2011

Academic Editor: M. Pagliassotti

Copyright © 2011 Delphine Fradin and Pierre Bougnères. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder influenced by interactions between genetic and environmental factors. Epigenetics conveys specific environmental influences into phenotypic traits through a variety of mechanisms that are often installed in early life, then persist in differentiated tissues with the power to modulate the expression of many genes, although undergoing time-dependent alterations. There is still no evidence that epigenetics contributes significantly to the causes or transmission of T2DM from one generation to another, thus, to the current environment-driven epidemics, but it has become so likely, as pointed out in this paper, that one can expect an efflorescence of epigenetic knowledge about T2DM in times to come.