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Journal of Nutrition and Metabolism
Volume 2012, Article ID 238056, 8 pages
Clinical Study

Inflammatory and Oxidative Stress Responses to High-Carbohydrate and High-Fat Meals in Healthy Humans

1Department of Endocrinology and Metabolism, Aarhus University Hospital, Tage-Hansensgade 2, 8000 Aarhus C, Denmark
2Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
3Discipline of Medicine, The University of Adelaide, Eleanor Harrald Building, Frome Road, Adelaide, SA 5005, Australia

Received 11 August 2011; Revised 4 October 2011; Accepted 16 October 2011

Academic Editor: C. S. Johnston

Copyright © 2012 S. Gregersen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The postprandial state is hypothesised to be proinflammatory and prooxidative, but the relative contributions of fat versus carbohydrate are unclear. Therefore, we examined inflammation and oxidative stress responses in serum and skeletal muscle before and after 1000 kcal meals, which were high in either fat or carbohydrate in 15 healthy individuals. Serum and muscle expression of IL6 was elevated 3 hours after each meal, independently of macronutrient composition ( 𝑃 < 0 . 0 1 ). Serum IL18 was decreased after high-fat meal only ( 𝑃 < 0 . 0 1 ). Plasma total antioxidative status and muscle Cu/Zn-superoxide dismutase were decreased after high-carbohydrate meal only ( 𝑃 < 0 . 0 5 ). We conclude that a high-carbohydrate meal may evoke a greater postprandial oxidative stress response, whereas both fat and carbohydrate increased IL6. We speculate that the observed increases in postprandial IL6, without increases in any other markers of inflammation, may indicate a normal IL6 response to enhance glucose uptake, similar to its role postexercise.