Neonatal SSRI Exposure Programs a Hypermetabolic State in Adult Mice
Figure 4
Cerebral cortex expression of TPH2 mRNA is increased in SSRI-exposed male mice. PCR was performed on midbrain and cerebral cortex homogenates obtained from control and SSRI-exposed mice (gray bars). Expression of the two tryptophan hydroxylase isoforms (TPH2 and TPH1) was normalized by GAPDH and ΔΔCT values were calculated to determine relative mRNA abundance. –10 mice from 5–8 litters per group; * versus control by ANOVA with the Holm-Sidak method for multiple comparisons.