Table of Contents Author Guidelines Submit a Manuscript
Journal of Nutrition and Metabolism
Volume 2012, Article ID 470656, 13 pages
http://dx.doi.org/10.1155/2012/470656
Review Article

Folate Intake and Markers of Folate Status in Women of Reproductive Age, Pregnant and Lactating Women: A Meta-Analysis

1Unit of Obstetrics and Gynecology, Department of Clinical Sciences Hospital ‘L. Sacco’ and Center for Fetal Research Giorgio Pardi, University of Milan, 20157 Milan, Italy
2University of Pécs, H-7623 Pécs, Hungary
3Division of Human Nutrition, Wageningen University and Research Centre, P.O. Box 8129, 6700 EV Wageningen, The Netherlands

Received 13 January 2012; Accepted 24 May 2012

Academic Editor: Cornelia M. Witthöft

Copyright © 2012 Cristiana Berti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Djukic, “Folate-responsive neurologic diseases,” Pediatric Neurology, vol. 37, no. 6, pp. 387–397, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. Homocysteine Lowering Trialists' Collaboration, “Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials,” British Medical Journal, vol. 316, no. 7135, pp. 894–898, 1998. View at Google Scholar · View at Scopus
  3. N. Milman, K. E. Byg, A. M. Hvas, T. Bergholt, and L. Eriksen, “Erythrocyte folate, plasma folate and plasma homocysteine during normal pregnancy and postpartum: a longitudinal study comprising 404 Danish women,” European Journal of Haematology, vol. 76, no. 3, pp. 200–205, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. C. P. Wild, C. Andersson, N. M. O'Brien, L. Wilson, and J. A. Woods, “A critical evaluation of the application of biomarkers in epidemiological studies on diet and health,” British Journal of Nutrition, vol. 86, no. 1, pp. S37–S53, 2001. View at Google Scholar · View at Scopus
  5. World Health Organization and Food and Agriculture Organization of the United Nations, “Folate and folic acid,” in Vitamin and Mineral Requirements in Human Nutrition, pp. 289–302, FAO/WHO Report, 2nd edition, 2004. View at Google Scholar
  6. H. Mc Nulty and J. M. Scott, “Intake and status of folate and related B-vitamins: considerations and challenges in achieving optimal status,” British Journal of Nutrition, vol. 99, supplement 3, pp. S48–S54, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Fekete, C. Berti, I. Cetin, M. Hermoso, B. V. Koletzko, and T. Decsi, “Perinatal folate supply: relevance in health outcome parameters,” Maternal and Child Nutrition, vol. 6, supplement 2, pp. S23–S38, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. M. K. Folate, “Supplementation in pregnancy,” The Cochrane Database of Systematic Reviews, no. 3, Article ID CD000183, 1997. View at Publisher · View at Google Scholar
  9. T. Tamura and M. F. Picciano, “Folate and human reproduction,” American Journal of Clinical Nutrition, vol. 83, no. 5, pp. 993–1016, 2006. View at Google Scholar · View at Scopus
  10. German Nutrition Society and Austrian Nutrition Society, “Swiss Society for Nutrition Research,” Reference Values for Nutrient Intake (D-A-CH), 2000.
  11. “Nutrient Reference Values for Australia and New Zealand,” National Health and Medical Research Council, 2005.
  12. O. Moreiras, A. Carbajal, L. Cabrera, and C. Cuadrado, “ìIngestas recomendadas de energiÏa y nutrientes para la poblacioÏn espanfiola,” î Tablas de composicion de alimentos, 11a edicioÏn revisada y ampliada, pp. 227-230, 2007.
  13. Nordic Nutrition Recommendations (NNR), Integrating Nutrition and Physical Activity, Nordic Council of Ministers, Copenhagen, Denmark, 4th edition, 2004.
  14. Livelli di Assunzione Raccomandati di Energia e Nutrienti per la Popolazione Italiana (LARN), Revision, Società Italiana di Nutrizione Umana (SINU), 1996.
  15. Panel on DRVs of the Committee on Medical Aspects of Food Policy (COMA), “Dietary reference values (DRVs) for food energy and nutrients for the UK,” Report on Health and Social Subjects 41, 1991. View at Google Scholar
  16. MRC Vitamin Study Research Group, “Prevention of neural tube defects: results of the Medical Research Council Vitamin Study,” The Lancet, vol. 338, no. 8760, pp. 131–137, 1991. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Berti, H. K. Biesalski, R. Gärtner et al., “Micronutrients in pregnancy: current knowledge and unresolved questions,” Clinical Nutrition, vol. 30, pp. 689–701, 2011. View at Google Scholar
  18. Y. Lamers, R. Prinz-Langenohl, S. Brämswig, and K. Pietrzik, “Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age,” The American Journal of Clinical Nutrition, vol. 84, pp. 156–161, 2006. View at Google Scholar
  19. K. Pietrzik, R. Prinz-Langenohl, Y. Lamers, E. S. Wintergerst, and S. Brämswig, “Randomized, placebo-controlled, double-blind study evaluating the effectiveness of a folic acid containing multivitamin supplement in increasing erythrocyte folate levels in young women of child-bearing age,” in Poster at the 18th International Nutrition Congress, Durban, South Africa, September, 2005.
  20. A. D. Mackey and M. F. Picciano, “Maternal folate status during extended lactation and the effect of supplemental folic acid,” American Journal of Clinical Nutrition, vol. 69, no. 2, pp. 285–292, 1999. View at Google Scholar · View at Scopus
  21. N. J. Wald, M. R. Law, J. K. Morris, and D. S. Wald, “Quantifying the effect of folic acid,” The Lancet, vol. 358, no. 9298, pp. 2069–2073, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. http://www.eurreca.org/everyone.
  23. E. L. Doets, J. P. van Wijngaarden, A. Szczeciñska et al., “Vitamin B12 intake and status and cognitive function in elderly people: a systematic review with meta-analyses”.
  24. C. Adank, T. J. Green, C. M. Skeaff, and B. Briars, “Weekly high-dose folic acid supplementation is effective in lowering serum homocysteine concentrations in women,” Annals of Nutrition and Metabolism, vol. 47, no. 2, pp. 55–59, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. I. A. Brouwer, M. van Dusseldorp, M. Duran et al., “Low-dose folic acid supplementation does not influence plasma methionine concentrations in young non-pregnant women,” British Journal of Nutrition, vol. 82, no. 2, pp. 85–89, 1999. View at Google Scholar · View at Scopus
  26. I. A. Brouwer, M. van Dusseldorp, C. M. G. Thomas et al., “Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial,” American Journal of Clinical Nutrition, vol. 1, no. 69, pp. 99–104, 1999. View at Google Scholar · View at Scopus
  27. G. J. Cuskelly, H. McNulty, and J. M. Scott, “Effect of increasing dietary folate on red-cell folate: implications for prevention of neural tube defects,” The Lancet, vol. 347, no. 9002, pp. 657–659, 1996. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Daly, J. L. Mills, A. M. Molloy et al., “Minimum effective dose of folic acid for food fortification to prevent neural-tube defects,” The Lancet, vol. 350, no. 9092, pp. 1666–1669, 1997. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Daly, J. L. Mills, A. M. Molloy et al., “Low-dose folic acid lowers plasma homocysteine levels in women of child-bearing age,” QJM—Monthly Journal of the Association of Physicians, vol. 95, no. 11, pp. 733–740, 2002. View at Google Scholar · View at Scopus
  30. Y. Lamers, R. Prinz-Langenohl, R. Moser, and K. Pietrzik, “Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women,” American Journal of Clinical Nutrition, vol. 79, no. 3, pp. 473–478, 2004. View at Google Scholar · View at Scopus
  31. I. P. Fohr, R. Prinz-Langenohl, A. Brönstrup et al., “5,10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women,” American Journal of Clinical Nutrition, vol. 75, no. 2, pp. 275–282, 2002. View at Google Scholar · View at Scopus
  32. T. J. Green, S. C. Murray, J. E. P. Rockell, and B. J. Venn, “Folic acid fortified milk increases blood folate and lowers homocysteine concentration in women of childbearing age,” Asia Pacific Journal of Clinical Nutrition, vol. 14, no. 2, pp. 173–178, 2005. View at Google Scholar · View at Scopus
  33. J. Ellison, P. Clark, I. D. Walker, and I. A. Greer, “Effect of supplementation with folic acid throughout pregnancy on plasma homocysteine concentration,” Thrombosis Research, vol. 114, no. 1, pp. 25–27, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. P. Lira, N. Barrena, A. Foradori, G. Gormaz, and G. Grebe, “Folate deficiency in pregnancy: effect of supplemental folate,” Sangre, vol. 34, no. 1, pp. 24–27, 1989. View at Google Scholar · View at Scopus
  35. N. N. Nogueira, J. V. Parente, and S. M. F. Cozzolino, “Mudanças na concentração plasmática de zinco e ácido fólico em adolescentes grávidas submetidas a diferentes esquemas de suplementação,” Cadernos de Saúde Pública, vol. 19, pp. 155–160, 2003. View at Google Scholar
  36. L. A. Houghton, K. L. Sherwood, R. Pawlosky, S. Ito, and D. L. O'Connor, “[6S]-5-Methyltetrahydrofolate is at least as effective as folic acid in preventing a decline in blood folate concentrations during lactation,” American Journal of Clinical Nutrition, vol. 83, no. 4, pp. 842–850, 2006. View at Google Scholar · View at Scopus
  37. Y. Lamers, (6S)-5-Methyltetrahydrofolate Compared to Folic Acid Supplementation: Effect on Risk Markers of Neural Tube Defects, Cuvillier, Goettingen, Germany, 2006.
  38. J. P. T. Higgins and S. Green, Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2, 2009.
  39. Institute of Medicine, Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Panthothenic Acid, Biotin, and Choline, National Academy Press, Washington, DC, USA, 2000.
  40. O. W. Souverein, C. Dullemeijer, P. van't Veer P, and H. van de Voet, “Transformations of summary statistics as input in meta-analysis for linear dose-response models on a logarithmic scale: a methodology developed within EURRECA,” BMC Medical Research Methodology, vol. 12, article 57, 2012. View at Google Scholar
  41. R. DerSimonian and N. Laird, “Meta-analysis in clinical trials,” Controlled Clinical Trials, vol. 7, no. 3, pp. 177–188, 1986. View at Google Scholar · View at Scopus
  42. J. Metz, R. Zalusky, and V. Herbert, “Folic acid binding by serum and milk,” American Journal of Clinical Nutrition, vol. 21, no. 4, pp. 289–297, 1968. View at Google Scholar · View at Scopus
  43. B. J. Venn, T. J. Green, R. Moser, J. E. Mckenzie, C. M. Skeaff, and J. Mann, “Increases in blood folate indices are similar in women of childbearing age supplemented with [6S]-5-methyltetrahydrofolate and folic acid,” Journal of Nutrition, vol. 132, no. 11, pp. 3353–3355, 2002. View at Google Scholar · View at Scopus