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Journal of Nutrition and Metabolism
Volume 2012, Article ID 545341, 9 pages
http://dx.doi.org/10.1155/2012/545341
Research Article

Accelerated Growth Rate Induced by Neonatal High-Protein Milk Formula Is Not Supported by Increased Tissue Protein Synthesis in Low-Birth-Weight Piglets

1INRA, UMR1348, PEGASE, 35590 Saint-Gilles, France
2INRA, Agrocampus Ouest, UMR1348, PEGASE, 35000 Rennes, France
3INSERM U699, 75018 Paris, France

Received 10 June 2011; Revised 26 August 2011; Accepted 13 October 2011

Academic Editor: Johannes B. van Goudoever

Copyright © 2012 Agnès Jamin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Low-birth-weight neonates are routinely fed a high-protein formula to promote catch-up growth and antibiotics are usually associated to prevent infection. Yet the effects of such practices on tissue protein metabolism are unknown. Baby pigs were fed from age 2 to 7 or 28 d with high protein formula with or without amoxicillin supplementation, in parallel with normal protein formula, to determine tissue protein metabolism modifications. Feeding high protein formula increased growth rate between 2 and 28 days of age when antibiotic was administered early in the first week of life. This could be explained by the occurrence of diarrhea when piglets were fed the high protein formula alone. Higher growth rate was associated with higher feed conversion and reduced protein synthesis rate in the small intestine, muscle and carcass, whereas proteolytic enzyme activities measured in these tissues were unchanged. In conclusion, accelerated growth rate caused by high protein formula and antibiotics was not supported by increased protein synthesis in muscle and carcass.