A Review of Psoriasis, a Known Risk Factor for Cardiovascular Disease and Its Impact on Folate and Homocysteine Metabolism

Figure 2

Proposed action of combination therapy, in addition to risk factors such as age, sex, hypertension, and dyslipidemia, homocysteine and inflammation lead to increased incidence of vascular disease. Consequently reducing inflammation with methotrexate and hyperhomocysteinemia by folic acid may lead to a decreased incidence of vascular disease for patients with psoriasis [24].