A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 Diabetes
Table 1
Body composition, tissue weights, food intake, total white blood cell counts, and adipokines.
C57BL/6J
C57BL/6N
C3H/HeJ
Con
HF
values
Con
HF
values
Con
HF
values
Final body weight (g)
32.4 ± 0.7
41.2 ± 0.9
<0.0001
33.7 ± 0.7
47.5 ± 0.7
<0.0001
30.5 ± 0.6
39.3 ± 1.1
<0.0001
Body composition
Lean (g)
21.8 ± 0.4
24.9 ± 0.3
<0.0001
22.1 ± 0.3
27.7 ± 0.5
<0.0001
19.8 ± 0.3
23.9 ± 0.5
<0.0001
Fat (g)
7.1 ± 0.4
12.0 ± 1.2
0.0006
9.6 ± 0.6
18.3 ± 0.6
<0.0001
6.7 ± 0.3
11.1 ± 0.6
<0.0001
Percent fat (%)
24.2 ± 1.0
31.8 ± 1.4
0.0018
29.4 ± 1.2
39.7 ± 0.9
<0.0001
25.2 ± 0.8
31.5 ± 0.8
<0.0001
Fat pad (g)
0.68 ± 0.08
1.67 ± 0.13
<0.0001
1.14 ± 0.11
1.69 ± 0.07
0.0067
0.52 ± 0.07
0.90 ± 0.06
0.0051
Feed efficiency (mg/kcal)
4.63 ± 0.38
8.41 ± 0.43
0.0011
5.28 ± 0.34
11.01 ± 0.43
<0.0001
3.24 ± 0.26
6.17 ± 0.36
0.0086
Food intake (g/day)
3.17 ± 0.04
2.74 ± 0.06
<0.0001
3.22 ± 0.04
2.98 ± 0.04
0.0002
3.19 ± 0.04
2.78 ± 0.06
<0.0001
Thymus (g)
0.042 ± 0.002
0.048 ± 0.003
0.1639
0.055 ± 0.004
0.076 ± 0.006
0.0096
0.019 ± 0.002
0.024 ± 0.002
0.0984
Spleen (g)
0.091 ± 0.005
0.098 ± 0.004
0.2754
0.106 ± 0.006
0.132 ± 0.009
0.0323
0.101 ± 0.004
0.123 ± 0.006
0.0066
WBC (1 105)
17.04 ± 1.80
18.55 ± 1.61
0.5350
21.69 ± 1.55
16.14 ± 1.72
0.0045
7.60 ± 0.71
11.48 ± 1.05
0.0252
Adipokines
Leptin (ng/mL)
3.64 ± 1.14
16.13 ± 3.67
0.0045
8.92 ± 1.87
44.96 ± 5.06
<0.0001
0.84 ± 0.15
11.08 ± 2.72
0.0014
Adiponectin (g/mL)
9.94 ± 0.76
7.45 ± 0.72
0.0068
6.36 ± 0.34
6.97 ± 0.25
0.1637
5.05 ± 0.40
5.13 ± 0.17
0.8315
Final body weight, body composition, food intake, tissue weight, and total white blood cell counts (WBC) and adipokines after 24 wk on a control (Con = AIN-93M) or a high fat diet (HF = 45% kcal from fat) in C57BL/6J, C57BL/6N, and C3H/HeJ mice. Values are means ± SE, mice in each group. values show the differences between dietary treatments within a given strain.
