A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 Diabetes
Table 2
Pathological scoring of hepatic tissue after 24 wk on a control or high fat diet.
C57BL/6J
C57BL/6N
C3H/HeJ
0
1
2
3
4
Mean
value
0
1
2
3
4
Mean
value
0
1
2
3
4
Mean
value
Steatosis
Con
10
1
0
0
0
0.09
0.0028
6
2
3
0
0
0.73
0.0020
10
0
0
0
0
0.00
0.0001
HF
2
4
6
1
0
1.46
0
2
1
2
8
3.23
1
4
5
4
0
1.86
Fibrosis
Con
0
0
0
0
0
0.00
—
11
0
0
0
0
0.00
0.0885
10
0
0
0
0
0.00
—
HF
0
0
0
0
0
0.00
10
3
0
0
0
0.23
14
0
0
0
0
0.00
Lobular inflammation
Con
11
0
0
0
0.00
0.0038
11
0
0
0
0.00
<0.0001
10
0
0
0
0.00
0.0641
HF
6
7
0
0
0.54
1
12
0
0
0.92
10
4
0
0
0.29
Portal inflammation
Con
11
0
0
0
0.00
0.0885
11
0
0
0
0.00
0.0001
10
0
0
0
0.00
—
HF
10
3
0
0
0.23
3
10
0
0
0.77
14
0
0
0
0.00
Balloon degeneration
Con
0
0
0
0.00
0.0062
11
0
0
0.00
<0.0001
10
0
0
0.00
<0.0001
HF
5
7
1
0.69
0
0
13
2.00
1
3
10
1.64
Frequency of steatosis (0–4), lobular and portal inflammation (0–3), fibrosis (0–4), and balloon degeneration (0–2), along with mean scores and values for control versus high fat diet within a given strain based on Chi-squared statistical analyses.
