A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 Diabetes

Table 4

Relative fold change of gene expression in the liver and bone marrow in mice fed a high fat diet compared to the control diet.

	C57BL/6J		C57BL/6N		C3H/HeJ
	HF	value	HF	value	HF	value
Liver
Fasn	1.55 ± 0.31	0.1748	2.20 ±	0.0248	1.23 ± 0.35	0.5934
Gpx1	0.89 ± 0.12	0.6197	1.54 ±	0.0127	1.31 ± 0.14	0.1653
Ppara	1.10 ± 0.16	0.5427	1.41 ±	0.0478	0.98 ± 0.10	0.8582
Slc2a2	0.99 ± 0.10	0.9792	1.56 ±	0.0096	1.08 ± 0.21	0.7756
Srebp1c	1.20 ± 0.26	0.4985	2.07 ± 0.51	0.0997	0.93 ± 0.21	0.8329
Tnf	1.76 ± 0.40	0.2237	1.12 ± 0.28	0.7238	2.09 ± 0.51	0.0703
Bone marrow
Fasn	0.94 ± 0.05	0.6811	0.94 ± 0.07	0.5619	1.20 ± 0.15	0.2388
Gpx1	0.56 ±	0.0053	1.45 ±	0.0228	1.05 ± 0.18	0.7983
Pparg	1.35 ± 0.39	0.4349	0.78 ± 0.10	0.1829	1.21 ± 0.18	0.3279

Mean fold regulation of genes involved in systemic metabolism and inflammation is presented for the animals on the high fat diet (45% kcal from fat) relative to their control (AIN-93M). All target genes were normalized to invariant control (Ppib). Symbol, , represents a significant difference () between dietary treatments within a given strain.