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Journal of Nutrition and Metabolism
Volume 2015, Article ID 823081, 12 pages
http://dx.doi.org/10.1155/2015/823081
Review Article

Fructose Metabolism and Relation to Atherosclerosis, Type 2 Diabetes, and Obesity

1Faculty of Public Health, Hedmark University College, P.O. Box 400, 2418 Elverum, Norway
2Norwegian University of Life Sciences, P.O. Box 5003, 1432 Aas, Norway

Received 17 April 2015; Revised 4 June 2015; Accepted 7 June 2015

Academic Editor: Michael B. Zemel

Copyright © 2015 Astrid Kolderup and Birger Svihus. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. M. Cohen, A. Teitelbaum, M. Balogh, and J. J. Groen, “Effect of interchanging bread and sucrose as main source of carbohydrate in a low fat diet on the glucose tolerance curve of healthy volunteer subjects,” The American Journal of Clinical Nutrition, vol. 19, no. 1, pp. 59–62, 1966. View at Google Scholar · View at Scopus
  2. L. H. Storlien, E. W. Kraegen, A. B. Jenkins, and D. J. Chisholm, “Effects of sucrose vs starch diets on in vivo insulin action, thermogenesis, and obesity in rats,” The American Journal of Clinical Nutrition, vol. 47, no. 3, pp. 420–427, 1988. View at Google Scholar · View at Scopus
  3. A. Giaccari, G. Sorice, and G. Muscogiuri, “Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes—mechanisms and potentials for treatment,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 19, no. 5, pp. 365–377, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. M. R. Laughlin, “Normal roles for dietary fructose in carbohydrate metabolism,” Nutrients, vol. 6, no. 8, pp. 3117–3129, 2014. View at Publisher · View at Google Scholar
  5. V. S. Malik, B. M. Popkin, G. A. Bray, J.-P. Després, W. C. Willett, and F. B. Hu, “Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis,” Diabetes Care, vol. 33, no. 11, pp. 2477–2483, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Dhingra, L. Sullivan, P. F. Jacques et al., “Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community,” Circulation, vol. 116, no. 5, pp. 480–488, 2007. View at Google Scholar
  7. A. T. Høstmark, “The Oslo Health Study: soft drink intake is associated with the metabolic syndrome,” Applied Physiology, Nutrition and Metabolism, vol. 35, no. 5, pp. 635–642, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. R. H. Lustig, “Fructose: metabolic, hedonic, and societal parallels with ethanol,” Journal of the American Dietetic Association, vol. 110, no. 9, pp. 1307–1321, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. P. J. Havel, “Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism,” Nutrition Reviews, vol. 63, no. 5, pp. 133–137, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. M. S. Segal, E. Gollub, and R. J. Johnson, “Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?” European Journal of Nutrition, vol. 46, no. 7, pp. 406–417, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. L. G. Sánchez-Lozada, M. Le, M. Segal, and R. J. Johnson, “How safe is fructose for persons with or without diabetes?” The American Journal of Clinical Nutrition, vol. 88, no. 5, pp. 1189–1190, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. J. S. White, “Challenging the fructose hypothesis: new perspectives on fructose consumption and metabolism,” Advances in Nutrition, vol. 4, no. 2, pp. 246–256, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. B. P. Marriott, N. Cole, and E. Lee, “National estimates of dietary fructose intake increased from 1977 to 2004 in the United States,” The Journal of Nutrition, vol. 139, no. 6, pp. S1228–S1235, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. Helsedirektoratet, “Utviklingen i norsk kosthold. Matforsyningsstatistikk,” 2013, (Norwegian), https://helsedirektoratet.no/Lists/Publikasjoner/Attachments/370/Utviklingen-i-norsk-kosthold-2013-matforsyningsstatistikk-IS-2116.pdf.
  15. United States Department of Argiculture, National Nutrient Database for Standard Reference, United States Department of Argiculture, 2012, http://ndb.nal.usda.gov/ndb/search/list?fg=&man=&lfacet=&count=&max=&sort=&qlookup=&offset=&format=Full&new=.
  16. J. S. White, “Straight talk about high-fructose corn syrup: what it is and what it ain't,” The American Journal of Clinical Nutrition, vol. 88, no. 6, pp. 1716S–1721S, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Ferder, M. D. Ferder, and F. Inserra, “The role of high-fructose corn syrup in metabolic syndrome and hypertension,” Current Hypertension Reports, vol. 12, no. 2, pp. 105–112, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Tappy and K.-A. Le, “Metabolic effects of fructose and the worldwide increase in obesity,” Physiological Reviews, vol. 90, no. 1, pp. 23–46, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Madero, S. E. Perez-Pozo, D. Jalal, R. J. Johnson, and L. G. Sánchez-Lozada, “Dietary fructose and hypertension,” Current Hypertension Reports, vol. 13, no. 1, pp. 29–35, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. H. F. Jones, R. N. Butler, and D. A. Brooks, “Intestinal fructose transport and malabsorption in humans,” The American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 300, no. 2, pp. G202–G206, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. A. S. Truswell, J. M. Seach, and A. W. Thorburn, “Incomplete absorption of pure fructose in healthy subjects and the facilitating effect of glucose,” The American Journal of Clinical Nutrition, vol. 48, no. 6, pp. 1424–1430, 1988. View at Google Scholar · View at Scopus
  22. J. E. Riby, T. Fujisawa, and N. Kretchmer, “Fructose absorption,” American Journal of Clinical Nutrition, vol. 58, no. 5, pp. S748–S753, 1993. View at Google Scholar · View at Scopus
  23. C. P. Corpe, C. F. Burant, and J. H. Hoekstra, “Intestinal fructose absorption: clinical and molecular aspects,” Journal of Pediatric Gastroenterology and Nutrition, vol. 28, no. 4, pp. 364–374, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. P. L. Beyer, E. M. Caviar, and R. W. McCallum, “Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adults,” Journal of the American Dietetic Association, vol. 105, no. 10, pp. 1559–1566, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Pimentel, H. C. Lin, P. Enayati et al., “Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 290, no. 6, pp. G1089–G1095, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. J. M. W. Wong, R. de Souza, C. W. C. Kendall, A. Emam, and D. J. A. Jenkins, “Colonic health: fermentation and short chain fatty acids,” Journal of Clinical Gastroenterology, vol. 40, no. 3, pp. 235–243, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. P. R. Gibson, E. Newnham, J. S. Barrett, S. J. Shepherd, and J. G. Muir, “Review article: fructose malabsorption and the bigger picture,” Alimentary Pharmacology & Therapeutics, vol. 25, no. 4, pp. 349–363, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. J. L. Madsen, J. Linnet, and J. J. Rumessen, “Effect of nonabsorbed amounts of a fructose-sorbitol mixture on small intestinal transit in healthy volunteers,” Digestive Diseases and Sciences, vol. 51, no. 1, pp. 147–153, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Dyer, I. S. Wood, A. Palejwala, A. Ellis, and S. P. Shirazi-Beechey, “Expression of monosaccharide transporters in intestine of diabetic humans,” American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 282, no. 2, pp. G241–G248, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. G. L. Kellett and E. Brot-Laroche, “Apical GLUT2—a major pathway of intestinal sugar absorption,” Diabetes, vol. 54, no. 10, pp. 3056–3062, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. C. M. F. Kneepkens, R. J. Vonk, and J. Fernandes, “Incomplete intestinal absorption of fructose,” Archives of Disease in Childhood, vol. 59, no. 8, pp. 735–738, 1984. View at Publisher · View at Google Scholar · View at Scopus
  32. V. Douard and R. P. Ferraris, “Regulation of the fructose transporter GLUT5 in health and disease,” American Journal of Physiology—Endocrinology and Metabolism, vol. 295, no. 2, pp. E227–E237, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. G. A. Bray, “How bad is fructose?” The American Journal of Clinical Nutrition, vol. 86, no. 4, pp. 895–896, 2007. View at Google Scholar · View at Scopus
  34. O. Bjorkman, M. Crump, and R. W. Phillips, “Intestinal metabolism of orally administered glucose and fructose in Yucatan miniature swine,” The Journal of Nutrition, vol. 114, no. 8, pp. 1413–1420, 1984. View at Google Scholar · View at Scopus
  35. O. Bjorkman and P. Felig, “Role of the kidney in the metabolism of fructose in 60-hour fasted humans,” Diabetes, vol. 31, no. 6, pp. 516–520, 1982. View at Publisher · View at Google Scholar · View at Scopus
  36. G. J. Litherland, E. Hajduch, G. W. Gould, and H. S. Hundal, “Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance,” Molecular and Cellular Biochemistry, vol. 261, no. 1, pp. 23–33, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Lam, K. Ng, K. L. Stanhope et al., “Effects of consuming dietary fructose versus glucose on de novo lipogenesis in overweight and obese human subjects,” Berkeley Scientific Journal, vol. 15, no. 2, 2011. View at Google Scholar
  38. L. Tappy and K.-A. Lê, “Does fructose consumption contribute to non-alcoholic fatty liver disease?” Clinics and Research in Hepatology and Gastroenterology, vol. 36, no. 6, pp. 554–560, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. K. L. Stanhope, “Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome,” Annual Review of Medicine, vol. 63, pp. 329–343, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. V. T. Samuel, “Fructose induced lipogenesis: from sugar to fat to insulin resistance,” Trends in Endocrinology and Metabolism, vol. 22, no. 2, pp. 60–65, 2011. View at Google Scholar · View at Scopus
  41. P. A. Mayes, “Intermediary metabolism of fructose,” American Journal of Clinical Nutrition, vol. 58, no. 5, pp. S754–S765, 1993. View at Google Scholar · View at Scopus
  42. J. Delarue, S. Normand, C. Pachiaudi, M. Beylot, F. Lamisse, and J. P. Riou, “The contribution of naturally labelled 13C fructose to glucose appearance in humans,” Diabetologia, vol. 36, no. 4, pp. 338–345, 1993. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Z. Sun and M. W. Empie, “Fructose metabolism in humans—what isotopic tracer studies tell us,” Nutrition& Metabolism, vol. 9, article 89, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. L. H. Smith Jr., R. H. Ettinger, and D. Seligson, “A comparison of the metabolism of fructose and glucose in hepatic,” The Journal of Clinical Investigation, vol. 32, no. 4, pp. 273–282, 1953. View at Publisher · View at Google Scholar · View at Scopus
  45. H. Sahebjami and R. Scalettar, “Effects of fructose infusion on lactate and uric acid metabolism,” The Lancet, vol. 297, no. 7695, pp. 366–369, 1971. View at Google Scholar · View at Scopus
  46. J.-M. Schwarz, Y. Schutz, F. Froidevaux et al., “Thermogenesis in men and women induced by fructose vs glucose added to a meal,” American Journal of Clinical Nutrition, vol. 49, no. 4, pp. 667–674, 1989. View at Google Scholar · View at Scopus
  47. C. Couchepin, L. Ê. Kim-Anne, M. Bortolotti et al., “Markedly blunted metabolic effects of fructose in healthy young female subjects compared with male subjects,” Diabetes Care, vol. 31, no. 6, pp. 1254–1256, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. V. Lecoultre, R. Benoit, G. Carrel et al., “Fructose and glucose co-ingestion during prolonged exercise increases lactate and glucose fluxes and oxidation compared with an equimolar intake of glucose,” The American Journal of Clinical Nutrition, vol. 92, no. 5, pp. 1071–1079, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. J. L. Kelsay, K. M. Behall, and W. M. Clark, “Glucose, fructose, lactate and pyruvate in blood, and lactate and pyruvate in parotid saliva in response to sugars with and without other foods,” American Journal of Clinical Nutrition, vol. 27, no. 8, pp. 819–825, 1974. View at Google Scholar · View at Scopus
  50. F. Theytaz, S. de Giorgi, L. Hodson et al., “Metabolic fate of fructose ingested with and without glucose in a mixed meal,” Nutrients, vol. 6, no. 7, pp. 2632–2649, 2014. View at Publisher · View at Google Scholar
  51. K. L. Teff, S. S. Elliott, M. Tschöp et al., “Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women,” The Journal of Clinical Endocrinology & Metabolism, vol. 89, no. 6, pp. 2963–2972, 2004. View at Publisher · View at Google Scholar · View at Scopus
  52. J. Girard, “The inhibitory effects of insulin on hepatic glucose production are both direct and indirect,” Diabetes, vol. 55, no. 2, pp. S65–S69, 2006. View at Publisher · View at Google Scholar · View at Scopus
  53. G. Boden, S. Salehi, P. Cheung et al., “Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue,” Obesity, vol. 21, no. 6, pp. 1208–1214, 2013. View at Publisher · View at Google Scholar · View at Scopus
  54. M. K. Hellerstein, J.-M. Schwarz, and R. A. Neese, “Regulation of hepatic de novo lipogenesis in humans,” Annual Review of Nutrition, vol. 16, pp. 523–557, 1996. View at Publisher · View at Google Scholar · View at Scopus
  55. E. Shrago, J. A. Glennon, and E. S. Gordon, “Comparative aspects of lipogenesis in mammalian tissues,” Metabolism: Clinical and Experimental, vol. 20, no. 1, pp. 54–62, 1971. View at Publisher · View at Google Scholar · View at Scopus
  56. Z. K. Guo, L. K. Cella, C. Baum, E. Ravussin, and D. A. Schoeller, “De nova lipognesis in adipose tissue of lean and obese women: application of deuterated water and isotope ratio mass spectrometry,” International Journal of Obesity, vol. 24, no. 7, pp. 932–937, 2000. View at Publisher · View at Google Scholar · View at Scopus
  57. F. Diraison, V. Yankah, D. Letexier, E. Dusserre, P. Jones, and M. Beylot, “Differences in the regulation of adipose tissue and liver lipogenesis by carbohydrates in humans,” Journal of Lipid Research, vol. 44, no. 4, pp. 846–853, 2003. View at Publisher · View at Google Scholar · View at Scopus
  58. A. Strawford, F. Antelo, M. Christiansen, and M. K. Hellerstein, “Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2H2O,” American Journal of Physiology—Endocrinology & Metabolism, vol. 286, no. 4, pp. E577–E588, 2004. View at Publisher · View at Google Scholar · View at Scopus
  59. C. Chascione, D. H. Elwyn, M. Davila, K. M. Gil, J. Askanazi, and J. M. Kinney, “Effect of carbohydrate intake on de novo lipogenesis in human adipose tissue,” American Journal of Physiology: Endocrinology and Metabolism, vol. 253, no. 6, pp. E664–E669, 1987. View at Google Scholar · View at Scopus
  60. A. Aarsland, D. Chinkes, and R. R. Wolfe, “Hepatic and whole-body fat synthesis in humans during carbohydrate overfeeding,” The American Journal of Clinical Nutrition, vol. 65, no. 6, pp. 1774–1782, 1997. View at Google Scholar · View at Scopus
  61. R. J. Stubbs, N. Mazlan, and S. Whybrow, “Carbohydrates, appetite and feeding behavior in humans,” The Journal of Nutrition, vol. 131, no. 10, pp. 2775S–2781S, 2001. View at Google Scholar · View at Scopus
  62. K. J. Acheson, Y. Schutz, T. Bessard, K. Anantharaman, J.-P. Flatt, and E. Jequier, “Glycoprotein storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man,” American Journal of Clinical Nutrition, vol. 48, no. 2, pp. 240–247, 1988. View at Google Scholar · View at Scopus
  63. E. J. Parks, L. E. Skokan, M. T. Timlin, and C. S. Dingfelder, “Dietary sugars stimulate fatty acid synthesis in adults,” Journal of Nutrition, vol. 138, no. 6, pp. 1039–1046, 2008. View at Google Scholar · View at Scopus
  64. O.-J. Park, D. Cesar, D. Faix, K. Wu, C. H. L. Shackleton, and M. K. Hellerstein, “Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase,” Biochemical Journal, vol. 282, no. 3, pp. 753–757, 1992. View at Google Scholar · View at Scopus
  65. K. L. Stanhope, J. M. Schwarz, N. L. Keim et al., “Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans,” The Journal of Clinical Investigation, vol. 119, no. 5, pp. 1322–1334, 2009. View at Publisher · View at Google Scholar · View at Scopus
  66. R. Crescenzo, F. Bianco, I. Falcone, P. Coppola, G. Liverini, and S. Iossa, “Increased hepatic de novo lipogenesis and mitochondrial efficiency in a model of obesity induced by diets rich in fructose,” European Journal of Nutrition, vol. 52, no. 2, pp. 537–545, 2013. View at Publisher · View at Google Scholar · View at Scopus
  67. T. J. Carden and T. P. Carr, “Food availability of glucose and fat, but not fructose, increased in the US between 1970 and 2009: analysis of the USDA food availability data system,” Nutrition Journal, vol. 12, article 130, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. K. M. Hirahatake, J. K. Meissen, O. Fiehn, and S. H. Adams, “Comparative effects of fructose and glucose on lipogenic gene expression and intermediary metabolism in HepG2 liver cells,” PLoS ONE, vol. 6, no. 11, Article ID e26583, 2011. View at Publisher · View at Google Scholar · View at Scopus
  69. J. R. Dushay, E. Toschi, E. K. Mitten, F. M. Fisher, M. A. Herman, and E. Maratos-Flier, “Fructose ingestion acutely stimulates circulating FGF21 levels in humans,” Molecular Metabolism, vol. 4, no. 1, pp. 51–57, 2014. View at Publisher · View at Google Scholar
  70. T. Bobbert, F. Schwarz, A. Fischer-Rosinsky et al., “Fibroblast growth factor 21 predicts the metabolic syndrome and type 2 diabetes in Caucasians,” Diabetes Care, vol. 36, no. 1, pp. 145–149, 2013. View at Publisher · View at Google Scholar · View at Scopus
  71. D. Faeh, K. Minehira, J.-M. Schwarz, R. Periasami, P. Seongsu, and L. Tappy, “Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men,” Diabetes, vol. 54, no. 7, pp. 1907–1913, 2005. View at Publisher · View at Google Scholar · View at Scopus
  72. V. Ha, J. L. Sievenpiper, R. J. De Souza et al., “Effect of fructose on blood pressure: a systematic review and meta-analysis of controlled feeding trials,” Hypertension, vol. 59, no. 4, pp. 787–795, 2012. View at Publisher · View at Google Scholar · View at Scopus
  73. M. F.-F. Chong, B. A. Fielding, and K. N. Frayn, “Mechanisms for the acute effect of fructose on postprandial lipemia,” The American Journal of Clinical Nutrition, vol. 85, no. 6, pp. 1511–1520, 2007. View at Google Scholar · View at Scopus
  74. A. Vedala, W. Wang, R. A. Neese, M. P. Christiansen, and M. K. Hellerstein, “Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans,” Journal of Lipid Research, vol. 47, no. 11, pp. 2562–2574, 2006. View at Publisher · View at Google Scholar · View at Scopus
  75. K. L. Stanhope and P. J. Havel, “Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance,” Current Opinion in Lipidology, vol. 19, no. 1, pp. 16–24, 2008. View at Publisher · View at Google Scholar · View at Scopus
  76. I. Marques-Lopes, D. Ansorena, I. Astiasaran, L. Forga, and J. A. Martínez, “Postprandial de novo lipogenesis and metabolic changes induced by a high-carbohydrate, low-fat meal in lean and overweight men,” The American Journal of Clinical Nutrition, vol. 73, no. 2, pp. 253–261, 2001. View at Google Scholar · View at Scopus
  77. J. D. Horton, J. L. Goldstein, and M. S. Brown, “SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver,” Journal of Clinical Investigation, vol. 109, no. 9, pp. 1125–1131, 2002. View at Publisher · View at Google Scholar · View at Scopus
  78. C. Tran, D. Jacot-Descombes, V. Lecoultre et al., “Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load,” British Journal of Nutrition, vol. 104, no. 8, pp. 1139–1147, 2010. View at Publisher · View at Google Scholar · View at Scopus
  79. L. C. Hudgins, M. K. Hellerstein, C. E. Seidman, R. A. Neese, J. D. Tremaroli, and J. Hirsch, “Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects,” Journal of Lipid Research, vol. 41, no. 4, pp. 595–604, 2000. View at Google Scholar · View at Scopus
  80. M. T. Timlin and E. J. Parks, “Temporal pattern of de novo lipogenesis in the postprandial state in healthy men,” American Journal of Clinical Nutrition, vol. 81, no. 1, pp. 35–42, 2005. View at Google Scholar · View at Scopus
  81. K.-A. Le, M. Ith, R. Kreis et al., “Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes,” The American Journal of Clinical Nutrition, vol. 89, no. 6, pp. 1760–1765, 2009. View at Publisher · View at Google Scholar · View at Scopus
  82. R. J. L. Allen and J. S. Leahy, “Some effects of dietary dextrose, fructose, liquid glucose and sucrose in the adult male rat,” British Journal of Nutrition, vol. 20, no. 2, pp. 339–347, 1966. View at Publisher · View at Google Scholar · View at Scopus
  83. I. Bergheim, S. Weber, M. Vos et al., “Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin,” Journal of Hepatology, vol. 48, no. 6, pp. 983–992, 2008. View at Google Scholar · View at Scopus
  84. K.-A. Lê, D. Faeh, R. Stettler et al., “A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans,” American Journal of Clinical Nutrition, vol. 84, no. 6, pp. 1374–1379, 2006. View at Google Scholar · View at Scopus
  85. G. Silbernagel, J. MacHann, S. Unmuth et al., “Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial,” British Journal of Nutrition, vol. 106, no. 1, pp. 79–86, 2011. View at Publisher · View at Google Scholar · View at Scopus
  86. J. L. Sievenpiper, R. J. de Souza, A. I. Cozma, L. Chiavaroli, V. Ha, and A. Mirrahimi, “Fructose vs. glucose and metabolism: do the metabolic differences matter?” Current Opinion in Lipidology, vol. 25, no. 1, pp. 8–19, 2014. View at Publisher · View at Google Scholar · View at Scopus
  87. S. Chiu, J. L. Sievenpiper, R. J. de Souza et al., “Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials,” European Journal of Clinical Nutrition, vol. 68, no. 4, pp. 416–423, 2014. View at Publisher · View at Google Scholar · View at Scopus
  88. S. Bravo, J. Lowndes, S. Sinnett, Z. Yu, and J. Rippe, “Consumption of sucrose and high-fructose corn syrup does not increase liver fat or ectopic fat deposition in muscles,” Applied Physiology, Nutrition and Metabolism, vol. 38, no. 6, pp. 681–688, 2013. View at Publisher · View at Google Scholar · View at Scopus
  89. J. M. Rippe and T. J. Angelopoulos, “Sucrose, high-fructose corn syrup, and fructose, their metabolism and potential health effects: what do we really know?” Advances in Nutrition, vol. 4, no. 2, pp. 236–245, 2013. View at Publisher · View at Google Scholar · View at Scopus
  90. M. Maersk, A. Belza, H. Stødkilde-Jørgensen et al., “Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study,” The American Journal of Clinical Nutrition, vol. 95, no. 2, pp. 283–289, 2012. View at Publisher · View at Google Scholar · View at Scopus
  91. R. D. Johnston, M. C. Stephenson, H. Crossland et al., “No difference between high-fructose and high-glucose diets on liver triacylglycerol or biochemistry in healthy overweight men,” Gastroenterology, vol. 145, no. 5, pp. 1016–1025, 2013. View at Publisher · View at Google Scholar · View at Scopus
  92. K. A. Page, O. Chan, J. Arora et al., “Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways,” The Journal of the American Medical Association, vol. 309, no. 1, pp. 63–70, 2013. View at Publisher · View at Google Scholar · View at Scopus
  93. J. B. Moore, P. J. Gunn, and B. A. Fielding, “The role of dietary sugars and de novo lipogenesis in non-alcoholic fatty liver disease,” Nutrients, vol. 6, no. 12, pp. 5679–5703, 2014. View at Publisher · View at Google Scholar
  94. S. W. Rizkalla, “Health implications of fructose consumption: a review of recent data,” Nutrition & Metabolism, vol. 7, article 82, 2010. View at Publisher · View at Google Scholar · View at Scopus
  95. A. Aarsland and R. R. Wolfe, “Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men,” Journal of Lipid Research, vol. 39, no. 6, pp. 1280–1286, 1998. View at Google Scholar · View at Scopus
  96. W. E. Connor, “Harbingers of coronary heart disease: dietary saturated fatty acids and cholesterol. Is chocolate benign because of its stearic acid content?” The American Journal of Clinical Nutrition, vol. 70, no. 6, pp. 951–952, 1999. View at Google Scholar · View at Scopus
  97. J. C. Cohen and R. Schall, “Reassessing the effects of simple carbohydrates on the serum triglyceride responses to fat meals,” American Journal of Clinical Nutrition, vol. 48, no. 4, pp. 1031–1034, 1988. View at Google Scholar · View at Scopus
  98. K. L. Teff, J. Grudziak, R. R. Townsend et al., “Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses,” The Journal of Clinical Endocrinology & Metabolism, vol. 94, no. 5, pp. 1562–1569, 2009. View at Publisher · View at Google Scholar · View at Scopus
  99. J. Hallfrisch, S. Reiser, and E. S. Prather, “Blood lipid distribution of hyperinsulinemic men consuming three levels of fructose,” The American Journal of Clinical Nutrition, vol. 37, no. 5, pp. 740–748, 1983. View at Google Scholar · View at Scopus
  100. S. Reiser, A. S. Powell, D. J. Scholfield, P. Panda, K. C. Ellwood, and J. J. Canary, “Blood lipids, lipoproteins, apoproteins, and uric acid in men fed diets containing fructose or high-amylose cornstarch,” The American Journal of Clinical Nutrition, vol. 49, no. 5, pp. 832–839, 1989. View at Google Scholar · View at Scopus
  101. J. P. Bantle, J. E. Swanson, W. Thomas, and D. C. Laine, “Metabolic effects of dietary fructose in diabetic subjects,” Diabetes Care, vol. 15, no. 11, pp. 1468–1476, 1992. View at Publisher · View at Google Scholar · View at Scopus
  102. J. E. Swanson, D. C. Laine, W. Thomas, and J. P. Bantle, “Metabolic effects of dietary fructose in healthy subjects,” American Journal of Clinical Nutrition, vol. 55, no. 4, pp. 851–856, 1992. View at Google Scholar · View at Scopus
  103. K. L. Stanhope, A. A. Bremer, V. Medici et al., “Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women,” Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 10, pp. E1596–E1605, 2011. View at Publisher · View at Google Scholar · View at Scopus
  104. I. Aeberli, P. A. Gerber, M. Hochuli et al., “Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: a randomized controlled trial,” The American Journal of Clinical Nutrition, vol. 94, no. 2, pp. 479–485, 2011. View at Publisher · View at Google Scholar · View at Scopus
  105. M. R. Diffenderfer and E. J. Schaefer, “The composition and metabolism of large and small LDL,” Current Opinion in Lipidology, vol. 25, no. 3, pp. 221–226, 2014. View at Publisher · View at Google Scholar · View at Scopus
  106. G. Livesey and R. Taylor, “Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies,” The American Journal of Clinical Nutrition, vol. 88, no. 5, pp. 1419–1437, 2008. View at Publisher · View at Google Scholar · View at Scopus
  107. M. M. Swarbrick, K. L. Stanhope, S. S. Elliott et al., “Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women,” British Journal of Nutrition, vol. 100, no. 5, pp. 947–952, 2008. View at Publisher · View at Google Scholar · View at Scopus
  108. D. David Wang, J. L. Sievenpiper, R. J. De Souza et al., “Effect of fructose on postprandial triglycerides: a systematic review and meta-analysis of controlled feeding trials,” Atherosclerosis, vol. 232, no. 1, pp. 125–133, 2014. View at Publisher · View at Google Scholar · View at Scopus
  109. I. Aeberli, M. Hochuli, P. A. Gerber et al., “Moderate amounts of fructose consumption impair insulin sensitivity in healthy young men: a randomized controlled trial,” Diabetes Care, vol. 36, no. 1, pp. 150–156, 2013. View at Publisher · View at Google Scholar · View at Scopus
  110. J. Lowndes, S. Sinnett, S. Pardo et al., “The effect of normally consumed amounts of sucrose or high fructose corn syrup on lipid profiles, body composition and related parameters in overweight/obese subjects,” Nutrients, vol. 6, no. 3, pp. 1128–1144, 2014. View at Publisher · View at Google Scholar · View at Scopus
  111. J. M. Rippe, “The metabolic and endocrine response and health implications of consuming sugar-sweetened beverages: findings from recent randomized controlled trials,” Advances in Nutrition, vol. 4, no. 6, pp. 677–686, 2013. View at Publisher · View at Google Scholar
  112. M. Hashemi, M. Yavari, N. Amiri et al., “Uric acid: a risk factor for coronary atherosclerosis?” Cardiovascular Journal of South Africa, vol. 18, no. 1, pp. 16–19, 2007. View at Google Scholar · View at Scopus
  113. T. C. Rodrigues, D. M. Maahs, R. J. Johnson et al., “Serum uric acid predicts progression of subclinical coronary atherosclerosis in individuals without renal disease,” Diabetes Care, vol. 33, no. 11, pp. 2471–2473, 2010. View at Publisher · View at Google Scholar · View at Scopus
  114. D. I. Feig, D.-H. Kang, and R. J. Johnson, “Uric acid and cardiovascular risk,” The New England Journal of Medicine, vol. 359, no. 17, pp. 1811–1821, 2008. View at Publisher · View at Google Scholar · View at Scopus
  115. C. L. Cox, K. L. Stanhope, J. M. Schwarz et al., “Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans,” Nutrition & Metabolism, vol. 9, article 68, 2012. View at Publisher · View at Google Scholar · View at Scopus
  116. D. D. Wang, J. L. Sievenpiper, R. J. de Souza et al., “The effects of fructose intake on serum uric acid vary among controlled dietary trials,” The Journal of Nutrition, vol. 142, no. 5, pp. 916–923, 2012. View at Publisher · View at Google Scholar · View at Scopus
  117. J. Perheentupa and K. Raivio, “Fructose-induced hyperuricaemia,” The Lancet, vol. 2, no. 7515, pp. 528–531, 1967. View at Google Scholar · View at Scopus
  118. C. M. Brown, A. G. Dulloo, G. Yepuri, and J.-P. Montani, “Fructose ingestion acutely elevates blood pressure in healthy young humans,” The American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 294, no. 3, pp. R730–R737, 2008. View at Publisher · View at Google Scholar · View at Scopus
  119. S. E. Perez-Pozo, J. Schold, T. Nakagawa, L. G. Sánchez-Lozada, R. J. Johnson, and J. L. Lillo, “Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response,” International Journal of Obesity, vol. 34, no. 3, pp. 454–461, 2010. View at Publisher · View at Google Scholar · View at Scopus
  120. V. H. Jayalath, J. L. Sievenpiper, R. J. de Souza et al., “Total fructose intake and risk of hypertension: a systematic review and meta-analysis of prospective cohorts,” Journal of the American College of Nutrition, vol. 33, no. 4, pp. 328–339, 2014. View at Publisher · View at Google Scholar
  121. V. Ha, V. H. Jayalath, A. I. Cozma, A. Mirrahimi, R. J. de Souza, and J. L. Sievenpiper, “Fructose-containing sugars, blood pressure, and cardiometabolic risk: a critical review,” Current Hypertension Reports, vol. 15, no. 4, pp. 281–297, 2013. View at Publisher · View at Google Scholar · View at Scopus
  122. M. Wang, M. Yu, L. Fang, and R. Hu, “Association between sugar-sweetened beverages and type 2 diabetes: a meta-analysis,” Journal of Diabetes Investigation, vol. 6, no. 3, pp. 360–366, 2015. View at Publisher · View at Google Scholar
  123. M.-F. Kong, I. Chapman, E. Goble et al., “Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects,” Peptides, vol. 20, no. 5, pp. 545–551, 1999. View at Publisher · View at Google Scholar · View at Scopus
  124. A. M. Grant, M. R. Christie, and S. J. H. Ashcroft, “Insulin release from human pancreatic islets in vitro,” Diabetologia, vol. 19, no. 2, pp. 114–117, 1980. View at Publisher · View at Google Scholar · View at Scopus
  125. D. L. Curry, “Effects of mannose and fructose on the synthesis and secretion of insulin,” Pancreas, vol. 4, no. 1, pp. 2–9, 1989. View at Publisher · View at Google Scholar · View at Scopus
  126. A. I. Cozma, J. L. Sievenpiper, R. J. de Souza et al., “Effect of fructose on glycemic control in diabetes: a systematic review and meta-analysis of controlled feeding trials,” Diabetes Care, vol. 35, no. 7, pp. 1611–1620, 2012. View at Publisher · View at Google Scholar · View at Scopus
  127. J. L. Sievenpiper, L. Chiavaroli, R. J. De Souza et al., “‘Catalytic’ doses of fructose may benefit glycaemic control without harming cardiometabolic risk factors: A small meta-analysis of randomised controlled feeding trials,” British Journal of Nutrition, vol. 108, no. 3, pp. 418–423, 2012. View at Publisher · View at Google Scholar · View at Scopus
  128. I. S. Hwang, H. Ho, B. B. Hoffman, and G. M. Reaven, “Fructose-induced insulin resistance and hypertension in rats,” Hypertension, vol. 10, no. 5, pp. 512–516, 1987. View at Publisher · View at Google Scholar · View at Scopus
  129. Y.-J. Huang, V. S. Fang, C.-C. Juan, Y.-C. Chou, C.-F. Kwok, and L.-T. Ho, “Amelioration of insulin resistance and hypertension in a fructose-fed rat model with fish oil supplementation,” Metabolism: Clinical and Experimental, vol. 46, no. 11, pp. 1252–1258, 1997. View at Publisher · View at Google Scholar · View at Scopus
  130. P. A. Crapo and O. G. Kolterman, “The metabolic effects of 2-week fructose feeding in normal subjects,” The American Journal of Clinical Nutrition, vol. 39, no. 4, pp. 525–534, 1984. View at Google Scholar · View at Scopus
  131. G. Grigoresco, S. W. Rizkalla, P. Halfon et al., “Lack of detectable deleterious effects on metabolic control of daily fructose ingestion for 2-mo in NIDDM patients,” Diabetes Care, vol. 11, no. 7, pp. 546–550, 1988. View at Publisher · View at Google Scholar · View at Scopus
  132. A. L. Sunehag, G. Toffolo, M. S. Treuth et al., “Effects of dietary macronutrient content on glucose metabolism in children,” Journal of Clinical Endocrinology & Metabolism, vol. 87, no. 11, pp. 5168–5178, 2002. View at Publisher · View at Google Scholar · View at Scopus
  133. R. D. Feinman and E. J. Fine, “Fructose in perspective,” Nutrition & Metabolism, vol. 10, no. 1, article 45, 2013. View at Publisher · View at Google Scholar · View at Scopus
  134. H. Beck-Nielsen, O. Pedersen, and H. O. Lindskov, “Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects,” The American Journal of Clinical Nutrition, vol. 33, no. 2, pp. 273–278, 1980. View at Google Scholar · View at Scopus
  135. J. Hallfrisch, K. C. Ellwood, O. E. Michaelis, S. Reiser, T. M. O'Dorisio, and E. S. Prather, “Effects of dietary fructose on plasma-glucose and hormone responses in normal and hyperinsulinemic men,” The Journal of Nutrition, vol. 113, no. 9, pp. 1819–1826, 1983. View at Google Scholar · View at Scopus
  136. K. C. Eiffert, R. B. McDonald, and J. S. Stern, “High sucrose diet and exercise: effects on insulin-receptor function of 12- and 24-mo-old Sprague-Dawley rats,” Journal of Nutrition, vol. 121, no. 7, pp. 1081–1089, 1991. View at Google Scholar
  137. Y. Wei and M. J. Pagliassotti, “Hepatospecific effects of fructose on c-jun NH2-terminal kinase: implications for hepatic insulin resistance,” American Journal of Physiology—Endocrinology and Metabolism, vol. 287, no. 5, pp. E926–E933, 2004. View at Publisher · View at Google Scholar · View at Scopus
  138. Y. Nagai, S. Yonemitsu, D. M. Erion et al., “The role of peroxisome proliferator-activated receptor gamma coactivator-1 β in the pathogenesis of fructose-induced insulin resistance,” Cell Metabolism, vol. 9, no. 3, pp. 252–264, 2009. View at Publisher · View at Google Scholar · View at Scopus
  139. S. Delbosc, E. Paizanis, R. Magous et al., “Involvement of oxidative stress and NADPH oxidase activation in the development of cardiovascular complications in a model of insulin resistance, the fructose-fed rat,” Atherosclerosis, vol. 179, no. 1, pp. 43–49, 2005. View at Publisher · View at Google Scholar · View at Scopus
  140. K. L. Stanhope, S. C. Griffen, B. R. Bair, M. M. Swarbrick, N. L. Keim, and P. J. Havel, “Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals,” The American Journal of Clinical Nutrition, vol. 87, no. 5, pp. 1194–1203, 2008. View at Google Scholar · View at Scopus
  141. L. T. Tran, V. G. Yuen, and J. H. McNeill, “The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension,” Molecular and Cellular Biochemistry, vol. 332, no. 1-2, pp. 145–159, 2009. View at Publisher · View at Google Scholar · View at Scopus
  142. J. Rodin, D. Reed, and L. Jamner, “Metabolic effects of fructose and glucose: implications for food intake,” American Journal of Clinical Nutrition, vol. 47, no. 4, pp. 683–689, 1988. View at Google Scholar · View at Scopus
  143. J. Rodin, “Comparative effects of fructose, aspartame, glucose, and water preloads on calorie and macronutrient intake,” The American Journal of Clinical Nutrition, vol. 51, no. 3, pp. 428–435, 1990. View at Google Scholar · View at Scopus
  144. L. Spitzer and J. Rodin, “Effects of fructose and glucose preloads on subsequent food-intake,” Appetite, vol. 8, no. 2, pp. 135–145, 1987. View at Publisher · View at Google Scholar · View at Scopus
  145. Z. S. Warwick and H. P. Weingarten, “Dynamics of intake suppression after a preload: role of calories, volume, and macronutrients,” The American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 266, no. 4, pp. R1314–R1318, 1994. View at Google Scholar · View at Scopus
  146. L. Tappy, J.-P. Randin, J.-P. Felber et al., “Comparison of thermogenic effect of fructose and glucose in normal humans,” The American Journal of Physiology—Endocrinology and Metabolism, vol. 250, no. 6, pp. E718–E724, 1986. View at Google Scholar · View at Scopus
  147. D. C. Simonson, L. Tappy, E. Jequier, J.-P. Felber, and R. A. DeFronzo, “Normalization of carbohydrate-induced thermogenesis by fructose in insulin-resistant states,” The American Journal of Physiology—Endocrinology and Metabolism, vol. 254, no. 2, pp. E201–E207, 1988. View at Google Scholar · View at Scopus
  148. J.-M. Schwarz, K. J. Acheson, L. Tappy et al., “Thermogenesis and fructose metabolism in humans,” American Journal of Physiology: Endocrinology and Metabolism, vol. 262, no. 5, pp. E591–E598, 1992. View at Google Scholar · View at Scopus
  149. J. Hugenholtz, “The lactic acid bacterium as a cell factory for food ingredient production,” International Dairy Journal, vol. 18, no. 5, pp. 466–475, 2008. View at Publisher · View at Google Scholar · View at Scopus
  150. M.-J. Gwak, S.-J. Chung, Y. J. Kim, and C. S. Lim, “Relative sweetness and sensory characteristics of bulk and intense sweeteners,” Food Science and Biotechnology, vol. 21, no. 3, pp. 889–894, 2012. View at Publisher · View at Google Scholar · View at Scopus
  151. R. S. Shallenberger, “Intrinsic chemistry of fructose,” Pure and Applied Chemistry, vol. 50, no. 11-12, pp. 1409–1420, 1978. View at Publisher · View at Google Scholar
  152. R. E. Wrolstad, Food Carbohydrate Chemistry, John Wiley & Sons, New York, NY, USA, 1st edition, 2012. View at Publisher · View at Google Scholar
  153. S. R. Blakely, J. Hallfrisch, S. Reiser, and E. S. Prather, “Long-term effects of moderate fructose feeding on glucose-tolerance parameters in rats,” The Journal of Nutrition, vol. 111, no. 2, pp. 307–314, 1981. View at Google Scholar · View at Scopus
  154. K. L. Stanhope and P. J. Havel, “Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup,” The American Journal of Clinical Nutrition, vol. 88, no. 6, pp. 1733S–1737S, 2008. View at Publisher · View at Google Scholar · View at Scopus
  155. J. L. Sievenpiper, R. J. de Souza, A. Mirrahimi et al., “Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis,” Annals of Internal Medicine, vol. 156, no. 4, pp. 291–304, 2012. View at Publisher · View at Google Scholar · View at Scopus
  156. J.-M. Schwarz, P. Linfoot, D. Dare, and K. Aghajanian, “Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets,” The American Journal of Clinical Nutrition, vol. 77, no. 1, pp. 43–50, 2003. View at Google Scholar · View at Scopus
  157. K. N. Frayn, P. Lund, and M. Walker, “Interpretation of oxygen and carbon dioxide exchange across tissue beds in vivo,” Clinical Science, vol. 85, no. 4, pp. 373–384, 1993. View at Google Scholar · View at Scopus
  158. E. E. Blaak and W. H. M. Saris, “Postprandial thermogenesis and substrate utilization after ingestion of different dietary carbohydrates,” Metabolism: Clinical and Experimental, vol. 45, no. 10, pp. 1235–1242, 1996. View at Publisher · View at Google Scholar · View at Scopus
  159. E. Ferrannini, “The theoretical bases of indirect calorimetry: a review,” Metabolism: Clinical and Experimental, vol. 37, no. 3, pp. 287–301, 1988. View at Google Scholar · View at Scopus
  160. L. Tappy and B. Mittendorfer, “Fructose toxicity: is the science ready for public health actions?” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 15, no. 4, pp. 357–361, 2012. View at Publisher · View at Google Scholar · View at Scopus
  161. M. B. Vos, J. E. Kimmons, C. Gillespie, J. Welsh, and H. M. Blank, “Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey,” The Medscape Journal of Medicine, vol. 10, no. 7, article 160, 2008. View at Google Scholar · View at Scopus
  162. M. Sland, M. Haugen, F.-L. Eriksen et al., “High sugar consumption and poor nutrient intake among drug addicts in Oslo, Norway,” British Journal of Nutrition, vol. 105, no. 4, pp. 618–624, 2011. View at Publisher · View at Google Scholar · View at Scopus