Clinical Study
Enteral Glutamine Administration in Critically Ill Nonseptic Patients Does Not Trigger Arginine Synthesis
| Tracer parameters and calculations | CON mean (SEM)/median (IQR) | ALA-GLN mean (SEM)/median (IQR) | Difference CON versus ALA-GLN () |
| Glutamine | | | | RA GLN M + 1 | | | | IV | 364.8 (57.5) | 390.4 (40.0) | 0.720 | EN | 787.5 (91.6) | 606.3 (88.3) | 0.173 | Endogenous RA GLN | 335.3 (62.3) | 322.04 (39.4) | 0.856 | TTR% GLN M + 1 | | | | IV | 4.88 (0.38) | 4.88 (0.33) | 0.997 | EN | 2.54 (0.35) | 2.44 (0.25) | 0.820 | Splanchnic extraction GLN | 48.2 (4.6) | 48.4 (3.6) | 0.965 | Citrulline | | | | RA CIT M + 5 | | | | IV | 26.5 (4.7) | 28.5 (5.5) | 0.780 | EN | 51.7 (23.7; 69.2) | 29.5 (20.8; 64.3) | 0.462 | Endogenous RA CIT | 26.5 (4.7) | 28.5 (5.5) | 0.780 | TTR% CIT M + 1 | | | | IV | 1.99 (0.33) | 1.13 (0.16) | 0.031 | EN | 4.44 (0.47) | 2.64 (0.46) | 0.015 | TTR% CIT M + 2 | | | | IV | 0.29 (0.14) | 0.21 (0.08) | 0.622 | EN | 1.08 (0.21) | 0.50 (0.19) | 0.057 | TTR% CIT M + 5 | | | | IV | 4.31 (0.85) | 4.06 (0.34) | 0.791 | EN | 2.49 (2.25; 2.94) | 1.98 (1.82; 2.29) | 0.207 | Splanchnic extraction CIT | 33.0 (7.7) | 44.8 (3.1) | 0.185 | Arginine | | | | RA ARG M + 2 | | | | IV | 76.6 (12.2) | 75.0 (6.0) | 0.907 | EN | 135.4 (106.8; 240.3) | 121.3 (17.0) | 0.374 | Endogenous RA ARG | 26.9 (25.0; 58.0) | 31.8 (6.1) | 0.336 | TTR% ARG M + 1 | | | | IV | 0.44 (0.13) | 0.35 (0.09) | 0.583 | EN | 0.97 (0.25) | 0.83 (0.15) | 0.624 | TTR% ARG M + 2 | | | | IV | 6.33 (0.76) | 6.00 (0.50) | 0.717 | EN | 3.73 (0.78) | 3.26 (0.46) | 0.593 | TTR% ARG M + 5 | | | | IV | 0.33 (0.06) | 0.35 (0.07) | 0.898 | EN | 0.25 (0.05) | 0.30 (0.05) | 0.500 | Splanchnic extraction ARG | 45.0 (6.2) | 41.8 (6.4) | 0.725 | Conversion rates | | | | Gln → Cit | 13.4 (4.2) | 6.3 (1.3) | 0.121 | Cit → Arg | 0 (0–2.2) | 1.3 (0.5–3.1) | 0.135 | Gln → Arg | 3.2 (1.0) | 2.4 (0.9) | 0.539 | Gln → Cit% of Gln | 4.45 (0.91) | 2.06 (0.42) | 0.026 | Gln → Cit% of Cit | 47.8 (7.8) | 24.8 (4.4) | 0.018 | Cit → Arg% of Cit | 0 (0–10.8) | 6.5 (1.3–12.5) | 0.370 | Cit → Arg% of Arg | 0 (0–7.4) | 5.3 (2.2–10.4) | 0.131 | Gln → Arg% of Gln | 1.3 (1.0–1.4) | 0.7 (0.3–1.3) | 0.370 |
|
|
RA in µmol/kg/h, endogenous RA in µmol/kg/h, splanchnic extraction in %, TTR in %, and in µmol/kg/h.
|