Inhibition of Intestinal α-Glucosidase and Glucose Absorption by Feruloylated Arabinoxylan Mono- and Oligosaccharides from Corn Bran and Wheat Aleurone
Table 1
Effect of ferulic acid and feruloylated arabinoxylan mono- and oligosaccharide extracts on α-glucosidase when sucrose or maltose was used as substrate.
(a) Caco-2 cells α-glucosidase
Extract
IC50 (mg/mL)
Sucrose
Maltose
Corn bran FAXmo
1.03 ± 0.04 (0.10)
1.65 ± 0.27 (0.16)
Wheat aleurone FAXmo
1.28 ± 0.05 (0.09)
1.34 ± 0.05 (0.09)
Ferulic acid
0.09 ± 0.01 (0.09)
0.08 ± 0.00 (0.08)
(b) Rat intestinal α-glucosidase
Extract
IC50 (mg/mL)
Sucrose
Maltose
Corn bran FAXmo
2.66 ± 0.64 (0.27)
4.8 ± 0.36 (0.48)
Wheat aleurone FAXmo
6.43 ± 0.83 (0.45)
5.08 ± 0.01 (0.35)
Ferulic acid
0.22 ± 0.13 (0.22)
0.22 ± 0.00 (0.22)
Acarbose
0.005 ± 0.00
0.003 ± 0.00
Values are presented as mean ± standard deviation ( for rat intestinal α-glucosidase and for Caco-2 studies). Data in the same column with the same superscript are not significantly different at . Data in parenthesis are IC50 values in ferulic acid equivalent (mg/mL). IC50 value is the sample concentration resulting in 50% inhibition of α-glucosidase activity. FAXmo means feruloylated arabinoxylan mono- and oligosaccharide extracts.
