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Journal of Nutrition and Metabolism
Volume 2016, Article ID 2978741, 8 pages
Clinical Study

Evaluation of the Anti-Inflammatory Effect of Locally Delivered Vitamin C in the Treatment of Persistent Gingival Inflammation: Clinical and Histopathological Study

1National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt
2Oral Pathology Department, Faculty of Oral & Dental Medicine, Cairo University, Giza, Egypt
3Oral Diagnosis, Medicine & Periodontology Department, Faculty of Oral & Dental Medicine, Cairo University, Giza, Egypt

Received 29 July 2016; Revised 25 October 2016; Accepted 30 October 2016

Academic Editor: Phillip B. Hylemon

Copyright © 2016 Nermin M. Yussif et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The purpose of this study is to investigate the role and efficiency of the locally injected vitamin C in the treatment of persistent gingival inflammation. Design. Twenty adult patients with persistent chronic gingival inflammation were included in this study. The same dose of sterile vitamin C was injected in gingival tissues after the completion of phase I therapy. Gingival biopsies were taken after total resolution of inflammation. The specimens were examined histologically, using H&E stain. Results. Clinical evaluation revealed great improvement of the injected sites with recall visits. Histopathological results revealed marked decrease in inflammatory cells and epithelial thickness and a higher number of newly formed subbasal capillaries. Conclusions. Vitamin C is an effective adjunctive treatment in reducing various degrees of chronic gingival inflammation.