Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised of Schisandra chinensis, Artemisia capillaris, and Aloe barbadensis

Table 1

Dose-correlated liver protection of the SAL composition in APAP/CCl₄ induced hepatotoxicity model.

Composition		Dose (mg/kg)	Dose (mg/kg); L498/R684/N-931	APAP (400 mg/kg)		CCL4 (25 µL/kg)
				Serum ALT (mean ± SD)	p values	Serum ALT (mean ± SD)	p values
Control (−)	10	—	0	37.4 ± 8.7	—	21.4 ± 4.7	—
APAP/CCL4	10	—	0	8558.6 ± 2297.6	—	10616.4 ± 3386.3	—
SAL	10	250	66.7/133.3/50	5600.4 ± 3399.8	0.05	7445.3 ± 2472.2	0.02
	10	325	86.7/173.3/65	4406.0 ± 3040.5	0.007	6417.8 ± 2421.0	0.003
	10	400	106.7/213.3/80	4065.1 ± 2046.9	0.004	5697.3 ± 2697.4	<0.001

Mice () were orally given composition SAL at doses of 250, 300, and 400 mg/kg at −48 hr, −24 hr, −and 2 hr before APAP or CCl₄ administration and +6 hr after induction of model suspended in 10% Tween-20. Hepatotoxicity models were induced using 400 mg/kg and 25 µL/kg APAP and CCl₄, respectively. APAP/CCL₄: the vehicle group of mice was induced by APAP/CCL₄ and did not receive the SAL. Serum ALT was determined at T24. Data are expressed as mean ± SD. L498 = Schisandra, R684 = Artemisia, N-931 = Aloe polysaccharide with aloesin.