Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised of Schisandra chinensis, Artemisia capillaris, and Aloe barbadensis
Table 4
Effect of SAL (400 mg/kg) on the major biomarkers of liver in CCl4 model.
Analyte
Control ()
CCL4 (25 µL/kg) ()
CCl4 (25 µg/kg) + SAL (400 mg/kg) ()
CCl4 (25 µg/kg) + UDCA (50 mg/kg) ()
ALT (U/L)
20.0 ± 6.5
9796.5 ± 2223.4
6466.6 ± 2696.5
7352.1 ± 3157.4
AST (U/L)
69.9 ± 16.1
5031.8 ± 1510.2
2794.0 ± 1427.2
2957.3 ± 1451.6
T. bilirubin (mg/dL)
0.17 ± 0.05
0.40 ± 0.11
0.31 ± 0.09
0.36 ± 0.10
Direct bilirubin (mg/dL)
0.00 ± 0.00
0.11 ± 0.03
0.04 ± 0.05
0.06 ± 0.05
Indirect bilirubin (mg/dL)
0.17 ± 0.05
0.29 ± 0.09
0.27 ± 0.07
0.30 ± 0.08
ALP (U/L)
76.6 ± 15.7
139.7 ± 65.5
115.0 ± 19.5
111.5 ± 33.7
Bile acid (μmol/L)
1.2 ± 0.4
30.1 ± 8.6
22.1 ± 7.4
28.9 ± 12.2
T. protein (g/dL)
4.50 ± 0.19
4.62 ± 0.20
4.61 ± 0.18
4.63 ± 0.18
Albumin (g/dL)
2.42 ± 0.13
2.64 ± 0.07
2.60 ± 0.09
2.60 ± 0.12
Globulin (g/dL)
2.08 ± 0.14
1.98 ± 0.15
2.01 ± 0.18
2.03 ± 0.14
Mice () were orally given composition SAL at doses of 400 mg/kg and UDCA at doses of 50 mg/kg at −48 hr, −24 hr, and −2 hr before intraperitoneal CCl4 injection and +6 hr after induction of model suspended in 10% Tween-20. Hepatotoxicity models were induced using 25 µL/kg of CCl4. Serum was collected at T24. Data are expressed as mean ± SD. .
