Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions

Figure 1

This bar graph shows the effects of various vitamin D3 compounds at a low concentration of 0.1 ng/mL on the mean fluorescent intensity (MFI) of CLIP⁺ B cells after TLR-engagement. This figure demonstrates the changes in MFI of CLIP and CLIP⁺ B220 subsets of B cells after CpG-induced TLR-9 activation. These results suggest that the active formulation of vitamin D3 may lead to a statistically significant reduction in CLIP expression on polyclonally activated splenic B cells. Administration of the human calcitriol of vitamin D3 () resulted in the greatest overall reduction in the MFI (257 versus a baseline of 701.1) for CLIP expression on stimulated B cells.