Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions

Figure 3

This bar graph also shows the effects of different vitamin D3 compounds at a concentration of 10 ng/mL on the MFI of CLIP expression and CLIP⁺ B220 subsets of B cells after TLR-activation. This graph compares the changes in MFI of CLIP and CLIP⁺ B220 subsets of B cells 15 hrs after administration of different compounds of vitamin D3 versus no treatment or DMSO (control). These results suggest that exogenously produced bioactive 1,25(OH)²D3 may be needed in higher doses of activated vitamin D3 in order to reduce the level of CLIP expression on polyclonally activated B cells (). Administration of human calcitriol again resulted in most significant reduction in CLIP expression on polyclonally activated B-lymphocytes.