Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions

Figure 5

This figure compares the impact of the various vitamin D compounds at 1.0 mg/dL on the density of cell surface CLIP expression and B220 subsets of B cells 15 hrs after treatment using the vitamin D3 compounds versus nontreatment or DMSO. These results suggest that the active formulation of vitamin D3 once again leads to a statistically significant reduction in CLIP expression on polyclonally activated splenic B cells even at a higher concentration of 10 mg/dL. Administration of the human calcitriol of vitamin D3 () resulted in the greatest overall reduction in the MFI (482.3 versus a baseline of 701.1 and 667.7 for the control) of CLIP expression on mitogen stimulated B cells.