Effect of Treatment with Salsalate, Menhaden Oil, Combination of Salsalate and Menhaden Oil, or Resolvin D1 of C57Bl/6J Type 1 Diabetic Mouse on Neuropathic Endpoints
Table 4
Effect of treatments of type 1 diabetes in C57Bl/6J mice on motor and sensory nerve conduction velocity, intraepidermal nerve fiber density (IENFD), and thermal sensitivity.
Determination
Control (18)
Diabetic group (16)
Diabetic + salsalate group (12)
Diabetic + menhaden oil group (11)
Diabetic + salsalate + menhaden oil group (14)
Diabetic + resolvin D1 group (13)
Motor nerve conduction velocity (m/sec)
41.1 ± 1.5
27.7 ± 1.0
35.2 ± 2.4
37.2 ± 1.1
39.2 ± 1.0
38.8 ± 1.1
Sensory nerve conduction velocity (m/sec)
29.9 ± 0.7
22.5 ± 0.6
27.0 ± 0.5
29.5 ± 0.8
30.2 ± 0.6
29.3 ± 0.5
IENFD (profiles/mm)
24.7 ± 0.7
14.6 ± 0.4
18.4 ± 0.4
21.3 ± 0.5
21.0 ± 0.6
20.4 ± 0.3
Thermal sensitivity (sec)
5.7 ± 0.2
8.6 ± 0.2
7.3 ± 0.2
6.6 ± 0.2
6.7 ± 0.1
5.8 ± 0.2
Data are presented as the mean ± SEM. compared to control mice. compared to diabetic mice. compared to diabetic + salsalate mice. Numbers in parentheses indicate the number of experimental animals.
