Research Article

Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial

Table 1

Participant characteristics by ATA assignment in the ATBC Study.

No
ATA
Yes
ATA
value

100100
Age (years)57.5 (4.9)57.8 (5.0)0.70
Height (cm)174 (5.9)174 (6.6)0.91
Weight (kg)79.6 (10.7)78.4 (12.5)0.40
BMI (kg/m2)26.2 (3.2)25.8 (3.5)0.36
Cigarettes per day20.3 (9.9)19.8 (8.9)0.80
Years of smoking35.1 (9.6)35.7 (9.5)0.68
Quit smoking at follow-up visit (%)29.022.00.21
Physically active (%)23.025.00.74
>Elementary school education (%)29.023.00.33
Dietary intake per day
 Total energy (kcal)2,775 (691)2,763 (695)0.60
 Fruit (g)235 (204)226 (161)0.80
 Vegetables (g)305 (113)319 (130)0.80
 Red meat (g)75.0 (31.4)75.6 (29.3)0.71
 Alcohol (ethanol, g)13.5 (16.8)14.7 (16.0)0.19
Serum concentrations
 Total cholesterol (mmol/L)
  Baseline6.4 (1.0)6.4 (1.1)0.87
  Follow-up6.0 (1.0)6.3 (1.2)0.20
 ATA (mg/L)
  Baseline12.5 (3.1)12.1 (2.9)0.33
  Follow-up12.9 (3.2)18.3 (4.2)<0.0001
-Carotene (μg/L)
  Baseline272 (255)240 (123)0.76
  Follow-up1,887 (1,886)2,014 (2,073)0.72
 Retinol (μg/L)
  Baseline576 (107)585 (122)0.82
  Follow-up597 (120)614 (136)0.41

All variables are from the baseline questionnaire unless otherwise indicated. Values are means (standard deviation) unless otherwise indicated.