Transient Decrease in Circulatory Testosterone and Homocysteine Precedes the Development of Metabolic Syndrome Features in Fructose-Fed Sprague Dawley Rats
Table 1
Plasma parameters.
4 weeks
12 weeks
24 weeks
Control
Fructose
Control
Fructose
Control
Fructose
Plasma glucose(mg/dL)
70 ± 2.4
79 ± 3.6
79 ± 1.6
84 ± 1.9
88 ± 1.3
76 ± 3.0
Plasma insulin (µU/mL)
12 ± 2.0
13 ± 4.0
14 ± 1.4
23 ± 2.4
17 ± 3.0
76 ± 19
AUC-glucose (mg/dL⋅min)
188 ± 4.6
203 ± 4.3
219 ± 6.6
228 ± 6.6
237 ± 9.5
220 ± 5.7
HOMA-IR
2 ± 0.34
3 ± 0.85
3 ± 0.31
5 ± 0.5
4 ± 0.6
18 ± 4.0
Plasma TG (mg/dL)
42 ± 4.0
47.3 ± 5.0
37 ± 2.4
52 ± 6.0
40 ± 1.9
54 ± 4.1
Cholesterol (mg/dL)
82 ± 4.0
82 ± 6.1
72 ± 2.2
89 ± 6.4
77 ± 3.08
79 ± 4.0
HDL (mg/dL)
67 ± 6.6
67 ± 4.1
56 ± 2.5
67 ± 5.2
68 ± 2.92
69 ± 3.0
2 × 3 ANOVA
Diet
Time
Diet × Time
Plasma insulin (µU/mL)
S
S
S
HOMA-IR
S
S
S
Plasma triglycerides
S
NS
NS
Values are in mean ± SE of 8 animals from each group at three time points. “” indicates statistical significance () of control and fructose-fed groups at each time point analyzed by Student’s -test. Statistical significance of diet, time, and diet time on individual parameters is also analyzed by two-way ANOVA. “S” indicates “significant” (); “NS” indicates “not significant.”
