Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice

Figure 3

Effect of short-term EET-A treatment on the expression of genes related to mitochondrial biogenesis and dynamics in the adipose tissue of mice. mRNA expression of PGC-1α (a), Drp1 (b), Fis1 (c), and Mfn1 (d) and protein expression of Mfn2 (e) in the adipose tissues of lean, HF diet fed (HF), HF diet EET-A-treated (EET-A), and PGC-1α-deficient (Ln shPGC-1α) mice. Results are mean ± SE, = 3-4, versus lean, versus HF, and versus HF+EET.

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