Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice

Figure 5

Effect of long-term EET-A treatment on the expression of PGC-1α, SIRT1, HO-1, and adiponectin in adipose tissue of mice fed HF diet. (a) Representative Western blots, (b) protein, and (c) mRNA levels of PGC-1α. Protein levels of (d) SIRT1, (e) HO-1, and (f) adiponectin. Data are normalized to β-actin for protein or GAPDH for mRNA. Results are mean ± SE, , versus lean, and versus HF.

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