Amino Acid Medical Foods Provide a High Dietary Acid Load and Increase Urinary Excretion of Renal Net Acid, Calcium, and Magnesium Compared with Glycomacropeptide Medical Foods in Phenylketonuria

Table 2

Nutrient profiles of the low-Phe diet in combination with AA-MF and GMP-MF¹.

	AA-MF	GMP-MF	p
Energy
kcal/d	2,266 ± 263	2,566 ± 204	0.26
kcal from MF/d	544 ± 100	763 ± 118	0.049
kcal from NF/d	1,722 ± 229	1,802 ± 127	0.77
Protein
g protein/d	79 ± 4	81 ± 6	0.70
g protein from MF/d	57 ± 5	55 ± 7	0.72
g protein from NF/d	21 ± 2	26 ± 4	0.32
Calcium : phosphorus ratio^3
Ca : P ratio/d	1.06 ± 0.14	1.19 ± 0.17	0.13
Ca : P ratio from MF/d	0.96 ± 0.14	1.22 ± 0.04	0.03
Ca : P ratio from NF/d	0.90 ± 0.27	1.38 ± 0.66	0.28
Vitamin D^2
IU vitamin D/d	630 ± 230	680 ± 167	0.75
IU vitamin D from MF/d	623 ± 182	593 ± 131	0.82
IU vitamin D from NF/d	54 ± 30	60 ± 26	0.81
Calcium^2
mg calcium/d	1,745 ± 274	1,898 ± 270	0.69
mg calcium from MF/d	1,282 ± 240	1,408 ± 264	0.58
mg calcium from NF/d^3	416 ± 78	484 ± 76	0.39
Magnesium
mg magnesium/d	568 ± 62	684 ± 113	0.27
mg magnesium from MF/d	362 ± 68	400 ± 68	0.43
mg magnesium from NF/d	206 ± 30	284 ± 77	0.37
Phosphorus
mg phosphorus/d	1,836 ± 228	1,749 ± 161	0.62
mg phosphorus from MF/d	1,183 ± 229	1,131 ± 195	0.80
mg phosphorus from NF/d	653 ± 58	618 ± 69	0.70
Potassium
mg potassium/d	3,249 ± 403	3,699 ± 383	0.40
mg potassium from MF/d	1,100 ± 307	1,388 ± 175	0.39
mg potassium from NF/d	2,149 ± 324	2,311 ± 302	0.70
Sodium
mg sodium/d^2	2,559 ± 298	3,487 ± 334	0.006
mg sodium from MF/d	499 ± 123	1,251 ± 176	0.017
mg sodium from NF/d^2	2,060 ± 271	2,236 ± 270	0.48

Values are means ± SE, based on 24-h food records, .
Vitamin D and calcium intake is based on 7 participants. One participant was omitted due to use of a therapeutic dose of Vitamin D and calcium throughout the study, prescribed for low BMD-for-age.
Calcium intake from natural foods had a significant genotype effect (p = 0.02). Participants with classical PKU consumed less calcium compared to those with variant PKU (means ± SE, 327 ± 48 mg calcium/d with classical PKU compared to 614 ± 57 mg calcium/d with variant PKU, p = 0.02). AA-MF: amino acid medical foods, GMP-MF: glycomacropeptide medical food, MF: medical foods, NF: natural food, and PRAL: potential renal acid load.