Dietary Strategies and Novel Pharmaceutical Approaches Targeting Serum ApoA-I Metabolism: A Systematic Overview

Table 2

Effect of boiled and filtered coffee, caffeine, and tea on fasting apoA-I concentrations.

First author, year	Food component/product	Study design and duration	Participants	Intake	Effects
Aro et al. (1987) [43]	Boiled versus filtered coffee versus tea	RCT crossover; 4 weeks	42 hypercholesterolemic subjects	8 cups/day	(i) No differences in serum apoA-I concentrations
Aro et al. (1990) [42]	Boiled versus filtered coffee	RCT crossover; 4 weeks	41 healthy subjects	2–14 cups/day	(i) No differences in serum apoA-I concentrations
van Dusseldorp et al. (1991) [47]	Filtered versus unfiltered coffee versus no coffee	RCT parallel; 79 days	64 healthy subjects	6 cups/day	(i) No differences in serum apoA-I concentrations
Burr et al. (1989) [44]	Decaffeinated versus no coffee	RCT crossover; 4 weeks	54 healthy subjects	>5 cups/day	(i) No differences in plasma apoA-I concentrations
Davies et al. (2003) [45]	Black tea versus caffeine versus caffeine free placebo	RCT crossover; 3 weeks	15 mildly hypercholesterolemic subjects	5 cups/day	(i) No differences in plasma apoA-I concentrations
Mozaffari-Khosravi et al. (2009) [46]	Sour tea versus black tea	RCT parallel; 1 month	53 patients with diabetes mellitus type 2	2 cups/day	(i) No differences in serum apoA-I concentrations