Review Article

Dietary Strategies and Novel Pharmaceutical Approaches Targeting Serum ApoA-I Metabolism: A Systematic Overview

Table 5

Effect of fiber on fasting apoA-I concentrations.

First author, yearFood component/productStudy design and durationParticipantsIntakeEffect

Anderson et al. (1991) [85]Oat versus wheat bran diet (similar macronutrient composition)RCT parallel
3 weeks
20 hypercholesterolemic men14 g/day(i) No differences in serum apoA-I concentrations

Cara et al. (1992) [86]Oat versus rice versus wheat bran versus wheat germ (similar macronutrient composition)RCT crossover
1 day
6 healthy subjects10 g as oat, rice, and wheat bran versus 4.2 g as wheat germ(i) No differences in serum apoA-I concentrations

Kashtan et al. (1992) [87]Oat versus wheat bran supplemented foodRCT parallel
2 weeks
32 subjects with a history of polypectomy and 32 healthy subjects6.8 g/1000 kcal/day(i) No differences in serum apoA-I concentrations

Stewart et al. (1992) [80]Oat bran versus control diet (similar macronutrient composition)RCT crossover
6 weeks
24 hypercholesterolemic subjects50 g/day(i) No differences in serum apoA-I concentrations

Uusitupa et al. (1992) [88]Oat versus wheat bran diet (similar macronutrient composition)RCT parallel
8 weeks
36 hypercholesterolemic subjects10.3 g/day(i) No differences in serum apoA-I concentrations

Zhang et al. (1992) [89]Oat versus wheat branRCT crossover
3 weeks
9 subjects with ileostomies4.9 versus 29.0 g/day(i) No differences in plasma apoA-I concentrations

Mekki et al. (1997) [90]High-fiber diet versus low fiber dietRCT parallel
4 weeks
31 mildly hypercholesterolemic subjects35 g/day(i) No differences in plasma apoA-I concentrations

Jenkins et al. (2002) [91]Low fat, low-cholesterol diet high versus low in β-glucan or psyllium fiber (similar macronutrient composition)RCT crossover
4 weeks
68 hyperlipidemic subjects8 g/day(i) 1.3% in serum apoA-I concentrations comparing the high with the low

Garcia et al. (2006) [92]Arabinoxylan supplement versus placeboRCT crossover
6 weeks
11 patients with impaired glucose tolerance15 g/day(i) 4.0% in serum apoA-I

Sola et al. (2007) [93]Low SFA diet supplemented with P. ovata husk versus P. ovata seedsRCT crossover
8 week
28 men with CVD10.5 g/day(i) No differences in fasting plasma apoA-I concentrations

Rondanelli et al. (2008) [94]β-Glucan versus rice bran supplemented foodRCT crossover
4 weeks
24 mildly hypercholesterolemic men15 versus 30 g/day(i) No differences in serum apoA-I concentrations

Dodin et al. (2008) [95]Flaxseed versus wheat germRCT parallel
12 months
199 healthy postmenopausal women40 g/day(i) 4.0% in serum apoA-I concentrations comparing flaxseed with wheat

Percentages calculated from the mean values; SFA: saturated fatty acids.