Metabolomic Insights into the Nutritional Status of Adults and Adolescents with Phenylketonuria Consuming a Low-Phenylalanine Diet in Combination with Amino Acid and Glycomacropeptide Medical Foods

Table 1

Participant characteristics¹.

	Adult males	Adult females	Minors^2
				Adult and minors	Adults only
Age, y	28 ± 9 (18–44)	30 ± 7 (23–49)	16 ± 1 (15–17)	0.003	0.64
BMI, kg/m^2	25.2 ± 3.6	26.9 ± 5.3	23.2 ± 2.4	0.29	0.34
BMI percentile	—	—	69.6 ± 23.7 (30–93)	—	—
Plasma Phe, µmol/L	770 ± 217 (367–1086)	658 ± 337 (201–1360)	706 ± 540 (224–1418)	0.63	0.52
Classical PKU, n	8	10	2	—	—
Variant PKU, n	2	5	3	—	—
Kuvan™ user, n	1	2	2	—	—

¹Data represent participant characteristic data collected at baseline (visit 1) for our clinical trial, n = 30 [8]. Values are means ± SD, and values in parenthesis represent the minimum and maximum. Subanalyses were done to compare adult male and female participants; ²of the five participants who were minors (<18 y), two were male and three were female; BMI, body mass index; PKU, phenylketonuria.