Association of Copper Status with Lipid Profile and Functional Status in Patients with Amyotrophic Lateral Sclerosis
Table 3
Association of Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) with copper and lipid biomarkers in patients with amyotrophic lateral sclerosis.
Variable
Standard error
95% CI
Hypothesis testing
Inferior
Superior
χ2
df
value
Model
79.42
8
<0.001
Interception
3.779
0.4886
2.821
4.736
59.824
1
<0.001
Dietary copper
−0.373
0.0784
−0.527
−0.219
22.646
1
<0.001
Plasma copper
−0.005
0.0023
−0.010
0.000
4.545
1
0.033
Serum ceruloplasmin
0.016
0.0081
0.000
0.032
4.046
1
0.044
Total cholesterol
−0.312
0.0959
−0.500
−0.124
10.611
1
0.001
LDL-cholesterol
0.314
0.0958
0.126
0.502
10.748
1
0.001
HDL-cholesterol
0.308
0.0943
0.123
0.493
10.686
1
0.001
Triglycerides
0.062
0.0190
0.025
0.099
10.568
1
0.001
Dependent variable: ALSFRS-R score. B: regression coefficient; 95% CI: 95% confidence interval; χ2: chi-square test; df: degrees of freedom; value: probability of the null hypothesis is true.
