Lactic Acid Bacteria Isolated from Japanese Fermented Fish (Funa-Sushi) Inhibit Mesangial Proliferative Glomerulonephritis by Alcohol Intake with Stress

Figure 4

Mesangiolysis in mice. (a)–(c) Azan staining of the glomerulus in the kidney. (a) The glomerulus in the kidney from a normal mouse fed with control diet (CD). Blue regions (white arrows) show collagen fiber. (b) The glomerulus in the kidney from a mouse fed with alcohol diet (AD). Blue regions (white arrows) show collagen fiber, which are increased compared to (a). (c) The glomerulus in the kidney from a mouse fed with AD containing Lb. paracasei. Blue regions (white arrows) show collagen fiber, which are reduced compared to (b). (d)–(f) Immunostaining of the glomerulus in the kidney. (d) The glomerulus in the kidney from a normal mouse fed CD. A mesangial cell (black arrow) is stained by desmin. (e) The glomerulus in the kidney from a mouse fed with AD. The number of mesangial cells (black arrows) is higher than in the normal kidney (d). (f) The glomerulus in the kidney from a mouse fed AD containing Lb. paracasei. The number of mesangial cells (black arrow) is fewer than that of animals fed AD (e).

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