The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of Thiol/Disulfide Redox State through the Upregulation of Glutathione Synthesis

Figure 3

TBARS (a), protein carbonyl (b) and NPSH (c) levels, GSH/GSSG ratio (d), δ-ALA-D activity (e), and gene expression of GCLcs (f) and GS (g) in the liver of diabetic rats fed high-fat diet and treated with jaboticaba peel powder or vehicle for 8 weeks (means ± SEM, ). Different from the control group (). ^#Different from the diabetic-vehicle group (TBARS, protein carbonyl, NPSH, GSH/GSSG ratio, and δ-ALA-D: ANOVA-Duncan’s test; GCLcs and GS: ANOVA-Dunnett's test; ). The gene expression data were normalized by β-actin gene expression, and mean ± SD were obtained from three independent repetitions. TBARS = thiobarbituric acid reactive substances; NPSH = nonprotein thiol group; GSH = reduced glutathione; GSSG = oxidised glutathione; δ-ALA-D = δ-aminolaevulinic acid dehydratase; GCLcs = glutamate-cysteine ligase, catalytic subunit; GS = glutathione synthase.

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