Hypercysteinemia, A Potential Risk Factor for Central Obesity and Related Disorders in Azores, Portugal
Table 2
Plasma aminothiol profile and its major determinants in Ponta Delgada (PDL) and Lisbon groups, according to gender.
All
Women
Men
PDL (101)
Lisbon (121)
PDL (61)
Lisbon (59)
PDL (40)
Lisbon (62)
Total plasma aminothiols
Cys (μM)
255 ± 47
185 ± 44
247 ± 47
182 ± 52
269 ± 43
188 ± 36
HCys (%)
18
4
13
5
25
3
Hcy (μM)
11 ± 3
10 ± 5
10 ± 3
8 ± 3
12 ± 4
11 ± 5
HHcy (%)
12
10
8
3
17
16
Cys-Gly (μM)
30 ± 6
27 ± 6
29 ± 6
26 ± 6
32 ± 6
28 ± 5
GSH (μM)
1.99 ± 0.6
1.88 ± 0.7
1.97 ± 0.6
1.93 ± 0.8
2.03 ± 0.6
1.83 ± 0.6
Substrate/product ratios
Hcy/Cys
0.04 ± 0.01
0.05 ± 0.03
0.04 ± 0.01
0.05 ± 0.02
0.05 ± 0.01
0.06 ± 0.03
GSH/Cys-Gly
0.07 ± 0.02
0.07 ± 0.03
0.07 ± 0.02
0.08 ± 0.03
0.06 ± 0.02
0.07 ± 0.03
Cys/GSH
140 ± 53
112 ± 48
138 ± 56
106 ± 43
144 ± 48
118 ± 52
Met/Cys
0.06 ± 0.02
0.10 ± 0.04
0.07 ± 0.02
0.10 ± 0.05
0.06 ± 0.02
0.10 ± 0.04
Aminothiol determinants
Met (μM)
16 ± 5
18 ± 7
16 ± 6
18 ± 7
16 ± 4
19 ± 7
Folate (ng/mL)
9 ± 3
8 ± 3
9 ± 3
9 ± 4
9 ± 3
7 ± 3
Deficiency (%)
0
3
0
2
0
5
Vit. B12 (pg/mL)
364 ± 160
445 ± 168
349 ± 179
449 ± 189
386 ± 125
440 ± 146
Deficiency (%)
19
6
21
5
15
7
Vit. B6 (ng/mL)
17 ± 10
17 ± 12
15 ± 9
15 ± 5
21 ± 11
19 ± 16
Deficiency (%)
6
2
8
3
3
0
GGT activity (U/L)
26 ± 21
20 ± 15
21 ± 17
14 ± 6
34 ± 23
27 ± 19
Values are presented as mean ± SD, except otherwise indicated. Figures in parentheses are the number of subjects (n). HCys, hypercysteinemia; HHcy, hyperhomocysteinemia. for Lisbon group vs. PDL group; for Lisbon women vs. PDL women; for Lisbon men vs. PDL men.
