Journal of Nutrition and Metabolism / 2019 / Article / Tab 1

Clinical Study

Intestinal Permeability Measured by Urinary Sucrose Excretion Correlates with Serum Zonulin and Faecal Calprotectin Concentrations in UC Patients in Remission

Table 1

Intestinal permeability and inflammation measured in urine, faeces, and serum samples at three time points during the study.

Probiotic group ()Placebo group ()
Week 0Week 6Week 12Week 0Week 6Week 12

Urinary sucrose excretion (μmol)17.8 ± 15.231.2 ± 23.825.4 ± 18.317.6 ± 11.421.3 ± 28.322.1 ± 28.3
Urinary L/R ratio0.02 ± 0.020.06 ± 0.050.04 ± 0.040.05 ± 0.030.05 ± 0.040.04 ± 0.03
Urinary S/E 5–24 h ratio0.04 ± 0.030.04 ± 0.020.04 ± 0.010.04 ± 0.020.04 ± 0.020.04 ± 0.02
Urinary S/E 24 h ratio0.04 ± 0.010.03 ± 0.010.04 ± 0.010.03 ± 0.010.03 ± 0.010.03 ± 0.01
Serum zonulin (ng/mL)58.3 ± 25.750.0 ± 17.449.6 ± 23.651.0 ± 22.245.8 ± 9.751.8 ± 17.9
Faecal zonulin (ng/mL)95.6 ± 52.3113.1 ± 69.189.6 ± 64.791.0 ± 53.3127.1 ± 100.9118.4 ± 91.9
C-reactive protein ( mg/mL)2/130/132/131/122/121/12
IFNγ (pg/mL)11.5 ± 7.017.4 ± 15.342.2 ± 42.58.4 ± 4.912.7 ± 8.819.3 ± 9.4
IL-10 (pg/mL)0.5 ± 0.70.4 ± 0.70.4 ± 0.50.6 ± 0.90.8 ± 1.40.3 ± 0.1
IL-6 (pg/mL)0.8 ± 0.80.7 ± 0.60.8 ± 0.50.7 ± 0.40.7 ± 0.50.8 ± 0.4
TNFα (pg/mL)2.2 ± 0.82.2 ± 0.82.3 ± 0.72.2 ± 0.62.3 ± 0.62.0 ± 0.4
Calprotectin (µg/g)17.011.021.046.065.556.0

L/R: lactulose/rhamnose ratio; S/E: sucralose/erythritol ratio. No significant differences between time periods or between groups were found. All values are in mean ± SD except for CRP (fraction) and calprotectin (median).