CNDP1, NOS3, and MnSOD Polymorphisms as Risk Factors for Diabetic Nephropathy among Type 2 Diabetic Patients in Malaysia

Table 6

Association of polymorphism in T2DM with and without nephropathy.

CNDP1 χ^2rs2346061		Malays				Chinese				Indians
		Multiplicative model		Dominant model	Recessive model	Multiplicative model		Dominant model	Recessive model	Multiplicative model		Dominant model	Recessive model
		Genotype (df = 2)	Allele (df = 1)	Major/major vs. others (df = 1)	Minor/minor vs. others (df = 1)	Genotype (df = 2)	Allele (df = 1)	Major/major vs. others (df = 1)	Minor/minor vs. others (df = 1)	Genotype (df = 2)	Allele (df = 1)	Major/major vs. others (df = 1)	Minor/minor vs. others (df = 1)
CNDP1	χ^2	—	0.499	0.566	—	1.242	0.476	0.325	1.099	—	6.844	4.597	—
rs2346061		0.7883	0.4799	0.4518	0.5410	0.5374	0.4902	0.5686	0.2944	0.0488	0.0089	0.0320	0.1390
CNDP1	χ^2	11.894	12.425	2.282	11.704	8.141	9.600	3.714	7.157	9.318	7.711	6.138	6.138
D18S880		0.0026	0.0004	0.1302	0.0006	0.0171	0.0019	0.0540	0.0075	0.0095	0.0055	0.0132	0.0132
MnSOD	χ^2	6.203	5.868	6.201	0.647	—	6.603	0.967	8.423	15.235	16.301	10.689	7.238
rs4880		0.0450	0.0154	0.0128	0.4210	0.0380	0.0101	0.3254	0.0037	49.2 × 10^−5	5.4 × 10^−5	0.0011	0.0071
NOS3	χ^2	—	5.263	0.499	—	—	6.731	7.490	—	—	7.204	7.642	—
rs1799983		0.0158	0.0218	0.4799	0.4350	0.0146	0.0095	0.0062	0.6667	0.0174	0.0073	0.0057	0.4518

indicates an association of polymorphisms and disease in a different mode of inheritance.