Review Article

Validity of Accelerometers for the Evaluation of Energy Expenditure in Obese and Overweight Individuals: A Systematic Review

Table 2

Characteristics of the included study and validity results.

ReferenceActivity monitor/locationGold standardVariables analysedProtocolValidity resultsConclusion

REE

[25]SWA (Inner View® Research Software 4.0)/triceps muscleIC, using Sensormedics Vmax-29NREEAt least 30 min of IC + SWA (data collected during the first 5–10 min excluded for allowing the acclimatisation, experiment conducted at thermos neutral environment and in the absence of external stimuli)(i) Women:
(1) Mean difference: 230.1 ± 690.4 kJ·d−1 ()
(2) Bland–Altman: LOA (1125; 1582 kJ·d−1)
(3) Pitman’s test: R = 0.034 ()
(4) Lin’s CCC: (95% CI) 0.579 (0.467; 0.691)
(ii) Men:
(1) Mean difference: 451.9 ± 937.2 kJ·d−1 ()
(2) Bland–Altman: LOA (1381; 2280 kJ·d−1)
(3) Pitman’s test: R = −0.221 ()
(4) Lin’s CCC: (95% CI) 0.583 (0.397; 0.768)
Poor agreement between SWA and IC for the assessment of REE

[29]SWA (Inner View® Research Software 6.1)/right upper arm over the triceps muscle)IC, using Deltatrac IIREEAt least 30 min of IC + SWA (data collected during the first 5–10 min excluded for allowing the acclimatisation, experiment conducted under standardized condition, after an overnight fast and after a resting period of at least 30 min)Data available for 63 subjects
Mean difference: 870.2 ± 991.6 kJ·d−1 ()
Pearson’s correlation: R = 0.826 ()
The overestimation of REE by SWA can be a limitation in physiological studies

[30]SWA (Inner View® Research Software 6.1)/right upper arm over the triceps muscleIC, using Deltatrac IIREEIC and SEESWAREEIC: experiment conducted under standardized conditions, after an overnight fast and after a resting period of at least 30 min, with the request not to smoke prior the experiment
SEESWA: EE continuously measured for 3 d. SEEep and SEElp data were analysed if the duration was at least 35 min, with the exclusion of the first and the last 5 min
(i) SEEep:
(1) Mean difference: 514.6 ± 895.4 kJ·d−1 ()
(2) Linear regression: R2 = 0.705 ()
(3) Bland–Altman: 6.2% of the values were outside the LOA (−715; −318 kJ·d−1)
(ii) SEElp:
(1) Mean difference: 569 ± 868.6 kJ·d−1 ()
(2) Linear regression: R2 = 0.717 ()
(3) Bland–Altman: 6.2% of the participants were outside the LOA (−761; −377 kJ·d−1)
The assessment of SEE for 3 nights for the estimation of REE is a promising approach in clinical practice, but authors suggest to subtract 10% of the assessed SEE with the SWA to predict REE in normal-weight, overweight, and obese individuals

[37]SWA (Inner View® Research Software 4.0)/right arm over the triceps muscle at the midpoint between the acromion and olecranon processesIC, using Sensormedics Vmax-29NREEAt least 20 min of IC + SWA (data collected during the first 5–10 min excluded for allowing the acclimatisation, experiment conducted after an overnight fast and after a resting period of 30 min)Mean difference: −288.7 kJ·d−1
Bland–Altman: LOA (−63; 89 kJ·d−1)
Pearson’s correlation: R = 0.88 ()
Specific algorithms for obese individuals are needed

[40]SWA/Inner View® Research Software 6.1/right upper arm over the triceps muscleIC, using Quark CPET, COSMEDREE30 min of IC + SWA (data collected during the first 10 min excluded for allowing the acclimatisation, experiment conducted under standardized condition, after an overnight fast)Women:
Mean difference: −173.2 kJ·d−1 ()
Pearson’s correlation: R = 0.58 ()
Pearson’s regression analysis: R = −0.54 ()
Men:
Mean difference: −37.7 kJ·d−1 ()
Pearson’s correlation: R = 0.73 ()
Pearson’s regression analysis: R = −0.11 ()
Despite the good accuracy showed by SWA, results were not more accurate than the established estimation equations. SWA does not represent a reliable alternative for measuring REE in obese subjects

EE during physical exercises (experiments conducted in a laboratory)

[26]SWA (model MF-SW, Inner View® Research Software 7.0 and 8.1)/center triceps brachii muscle, midway between the elbow and the shoulderIC, Oxycon™ Mobile portable system (CareFusion Inc., San Diego, CA)PAEE1 structured routine (90 min) and 1 semistructured routine (64 min), both including a wide range of activities of sedentary/light, moderate, and vigorous intensity. Participants were instructed to consume only water for at least 3 hours prior to the testStructured routine:
Mean difference SWA 7.0-IC: 241.8 kJ ( in both women and men)
Mean difference SWA 8.0-IC: 187.4 kJ ( in both women and men)
ICC SWA 7.0-IC: 0.89
ICC SWA 8.0-IC: 0.89
Bland–Altman: no proportional bias for both SWA versions
Semistructured routine:
Mean difference SWA 7.0-IC: 206.7 kJ ()
Mean difference SWA 8.0-IC: 51.9 kJ ()
ICC SWA 7.0-IC: 0.66
ICC SWA 8.0 IC: 0.90
Bland–Altman: narrower limits of agreement for SWA 8.0
Both SWA 7.0 and 8.1 overestimated EE during the structured routine when compared with IC but during the semistructured routine SWA 8.0 provided an estimate of EE not different than that of IC, showing a greater applicability in living conditions

[28]Fitbit Charge 3-axis accelerometer (Fitbit Inc., San Francisco, California, USA)/wristIC, using Parvo TrueOne 2400 (Parvo Medics, East Sandy, UT, USA)PAEETwo walking stages at 80.5 m/min and 107.3 m/min and two running stages at 134.1 m/min and 160.9 m/min, with 5 min rest periods between each stageWalk at 80.5 m/min:
Overestimation of PAEE by 21.4% ()
Walk at 107.3 m/min:
Underestimation of PAEE by 11.2% ()
Jog at 134.1 m/min:
Underestimation of PAEE by 13.7% ()
Jog at 160.9 m/min:
Underestimation of PAEE by 22.5% ()
Caution should be exercised when considering caloric expenditure data from Fitbit Charge

[31]SWA (Inner View® Research Software 6.1)/right arm over the triceps muscle at the midpoint between the acromion and olecranon processesIC, using K4b2 COSMEDPAEEBrief warm-up period followed by two 10 min stages of rowing at 50% (low intensity) and 70% (moderate intensity) of each subject’s predetermined VO2 max wearing SWA + K4b2 COSMED, with a 20 min rest between each stage, in which food consumption was forbidden (at least 3 h fast and at least 3 h abstention from any physical activity before the test, SWA is worn for 15 min before data collection)50% VO2max:
Mean difference: 38 ± 385 kJ·min−1 ()
Bland–Altman: LOA (−11; 4 kJ·min−1)
Pearson’s correlation: R = 0.82 ()
70% VO2max:
No significant difference: ()
Bland–Altman: LOA (4; 5 kJ·min−1)
Pearson’s correlation: R = 0.87 ()
Specific algorithms to improve the accuracy of SWA to estimate EE at various intensities are needed

[33]ActiGraph GT3X+ 3-axis accelerometer (ActiGraph, Pensacola, Florida, USA)/waistIC, using K4b2 COSMEDPAEE80 min, semistructured activity protocol, performing ≥12 activities from a list of 21 choices, including sedentary activities, household activities, and ambulatory and cycling activitiesUnderestimation of PAEE by 26%ActiGraph underestimations of PAEE were most likely driven by the periods of time during the protocol in which the subjects performed household activities

[34]SWA (Inner View® Research Software 6.1)/rear part of the right armIC, using Vmax Spectra (Sensormedics)PAEEWalking protocol: Session 1, velocity = 3 km/h, 0% incline; session 2, velocity = 4 km/h, 0% incline; and session 3, velocity = 5 km/h, 5% incline3 km/h, 0% incline:
Mean deviations from IC: 81.19 ± 23.81%
Pearson’s correlation: R = 0.79 ()
4 km/h, 0% incline:
Mean deviations from IC: 78.18% ± 33.96%
Pearson’s correlation: R = 0.63 ()
5 km/h, 5% incline:
Mean deviations from IC −7.88% ± 16.07%
Pearson’s correlation: R = 0.74 ()
Good accuracy of SWA for measuring EE in individuals with diabetes during walking under controlled conditions, probably obtained thanks to the reasonable duration of the protocol (not too short)

[9]RT3 triaxial accelerometer)/and TriTrac-R3D Research ergometer (containing 3 accelerometers)/waist line above each hipIC, using Sensormedics Vmax-29NPAEE (calculated as the difference between pre-exercise EE and exercise EE). EERT3 and EE TriTrac-R3D = calculated using Weir’s equation5 min walking at 2, 3, and 4 km/h, successively, at 4% grade on a motorized treadmill, wearing RT3 and the TriTrac-R3D + Sensormedics Vmax-29N (2 minutes of warming up before initiation of each walking condition, each walking condition separated by a 10 sec period at an intermediate speed). Pre-exercise EE was determined with the subject seated in a comfortable thermal environment, 2 hours after lunchData available for 8 subjects
RT3:
Overestimation of PAEE by 30.6% ± 45.5% ()
Bland–Altman: LOA (−117; 75 kJ/min)
TriTrac-R3D:
Overestimation of PAEE by 54.9.0% ± 65.0% ()
Bland–Altman: LOA (−151; 75 kJ/min)
Mean PAEE did not differ significantly between methods within the range of walking speeds tested. However, there was a trend toward overestimation of PAEE by the TriTrac-R3D

[36]SWA (Inner View® Research Software 4.0)/Triceps muscleIC, using Sensormedics Vmax-29NPAEE5 min pedalling on a cycle ergometer at 60 rpm at a fixed load of 60 watts, 5 min stain stepping on a 16 cm bench, 5 min walking on a motorized treadmill at 3 km/h, wearing SWA + Sensormedics Vmax-29N (experiments conducted 2 h after lunch)Cycle ergometer:
Mean difference: 3.8 ± 6.5 kJ·min−1
ICC: 0.18 (95% CI = −0.20; 0.53) Stepping:
Mean difference: 7.1 ± 7.5 kJ·min−1
ICC: 0.06 (95% CI = −0.32; 0.43)
Treadmill:
Mean difference: 7.6 ± 8.8 kJ·min−1
ICC: 0.18 (95% CI = −0.40; 0.45)
Bland–Altman: no agreement for all the three activities
Specific algorithms for obese individuals are needed

[37]Kenz Lifecorder EX accelerometer (LC; Suzuken Co. Ltd., Nagoya, Japan)/midline of the right thigh on a belt at the level of the waistIC, by using Parvo Medics TrueOne 2400, Sandy, UTPAEESix 5-minute stages of walking on a treadmill starting at 1.5 mph and increasing to 2.0 mph, 2.5 mph, 3.0 mph, 3.5 mph, and 4.0 mph while grade was constant at 0% for the duration of the testMean difference in all the samples
1.5 mph: 32.6 kJ·min−1 ()
2.0 mph: 15.5 kJ·min−1 ()
3.0 mph: 13.4 ·min−1 ()
3.5 mph: 18.0 kJ·min−1 ()
4 mph: 12.6 kJ·min−1 ()
Overweight BMI:
Significant underestimation at speeds of 1.5 mph (), 2.0 mph (), 2.5 mph (), 3.0 mph (), and 4.0 mph ()
Obese BMI:
Significantly underestimation at all speeds except 3.0 mph (1.5 mph (), 2.0 mph (), 2.5 mph (), 3.5 mph (), and 4.0 mph ())
The device does not offer the accuracy needed to provide precise feedback on EE for individuals with varying BMI levels

[38]SWA Mini (Inner View® Research) Software 7.0)/upper armIC, using Parvo Medics TrueOne® 2400 Metabolic Measurement SystemPAEETwo 5 d experimental conditions separated by a minimum 7 d washout: SIT condition for 8 h/d (seated) or STAND-SIT condition for 8 h/d (alternating between a standing and seated work posture every 30 min). Experiments conducted at a controlled temperature, after a fasted state ≥10 h and after abstention from alcohol, caffeine, and moderate and vigorous physical activities for 24 h before the testData available for 14 subjects
STAND:
Mean difference: −0.4 ± 0.7 kJ·min−1 ()
Pearson’s correlation: R = 0.73 ()
Bland–Altman: LOA (−1.10; 1.28 kJ·min−1)
SIT:
Mean difference: 0.5 ± 0.7 kJ·min−1 ()
Pearson’s correlation: R = 0.82 ()
Bland–Altman: LOA (−1.40; 0.51 kJ·min−1)
SWA can provide reasonable EE estimates during STAND, while PAEE during SIT showed a modest overestimation. Further modifications to the SWA mini algorithms are required to improve the accuracy of EE

TEE and PAEE in free-living conditions

[27]Actical physical activity monitor omnidirectional accelerometer (Philips Respironics, Inc., Bend, Ore., USA)/waist or wrist SWA/upper part of the dominant arm
IDEEA accelerometer (MiniSun LLC, Fresno, Calif., USA, five biaxial accelerometer nodes)/5 sensors that are placed on the body: 1 on the chest, 2 on the front of the thighs, and 2 on the feet
DLWTEE and AEETEE measured by DLW for 2 weeks and by accelerometers for 1 week (only the week that corresponded with wearing the activity monitors was used for analysis). AEEDLW was calculated as TEE − (RMR + (0.1 × TEE)), where IC was measured with Deltatrac II metabolic car(i) Actical waist AEE:
(1) Mean difference: −466.01 kJ/d−1 ()
(2) Bland–Altman: R2 = 0.197 ()
(ii) Actical wrist AEEL:
(1) Mean difference: 813.9 kJ/d−1 ()
(2) Bland–Altman: R2 = 0.007 ()
(iii) SWA TEE:
(1) Mean difference: −251 kJ/d−1 ()
(2) Bland–Altman: R2 = 0.054 ()
(iii) SWA AEE:
(1) Mean difference: −1745 kJ/d−1 ()
(2) Bland–Altman: R2 = 0.286 ()
(iv) IDEEA TEE:
(1) Mean difference: 509.2 kJ/d−1 ()
(2) Bland–Altman: R2 = 0.035 ()
(v) IDEEA AEE:
(1) Mean difference: 454.8 kJ/d−1 ()
(2) Bland–Altman: R2 = 0.080 ()
The performance of the Actical was poor, while the IDEEA accurately estimated AEE when compared with DLW, and both the Sensewear and the IDEEA produced relatively accurate estimates of TEE

[32]Caltrac accelerometerDLWTEE (kJ·d−1) TEECaltrac = calculated using an equation that included weight, height, age, gender, and body accelerationsTEE measured by DLW for 2 weeks accelerometer on days 1, 3, 6, 8, and 12, during the time the subjects were awakeMean difference: 77 kJ·d−1
Pearson’s regression: R = 0.33 ()
Bland–Altman: large individual differences
Equations used for predicting EE from accelerometer are inaccurate at individual level

[35]SWA (Inner View® Research Software 6.1 and 5.1)/over the right triceps muscleDLWTEEDLW (kJ·d−1) and AEEDLW (calculated as 0.9 TEE − RMR measured by IC on a Deltatrac II respiratory gas analyser); TEESWA (kJ·d−1) and AEESWA (calculated as 0.9 TEE − RMR estimated using the Harris–Benedict equation)TEE and AEE measured by DLW and SWA for 2 weeksTEE SWA 6.1:
Mean difference: 117 ± 941 kJ·d−1
ICC: 0.896
Pearson’s correlation: R = 0.893 ()
Bland–Altman: all values except one with LOA of 1882 kJ
TEE SWA 5.1:
Mean difference: 105 ± 883 kJ d−1
ICC: 0.904
Pearson’s correlation: R = 0.901 ()
Bland–Altman: all values within LOA of 1766 kJ
AEE SWA 6.1
Mean difference: −653 ± 828 kJ·d−1
ICC: 0.643
Pearson’s correlation: R = 0.760 ()
Bland–Altman: all values except one within LOA of 1657 kJ
AEE SWA 5.1:
Mean difference: −452 ± 774 kJ·d−1
ICC: 0.720
Pearson’s correlation: R = 0.786 ()
Bland–Altman: all values except two within LOA of 1548 kJ
Measures of TEE from DLW and the SWA were strongly correlated and demonstrated strong agreement, and the Bland–Altman analysis revealed no systematic bias. SWA underestimated AEE but measures of AEE from DLW and SWA were strongly correlated and demonstrated moderate agreement, and the Bland–Altman analysis revealed no systematic bias

[9]RT3 triaxial accelerometer and TriTrac-R3D research ergometer (containing 3 accelerometers)/waist line above each hipDLWPAEE (PAEEDLW = TEE × 0.9 −RMRIC, PAEERT3 and PAEE TriTrac-R3D = PAEE/predicted RMR × RMRIC)PAEE measured for 2 weeksRT3
Mean difference: −284.5 kJ·d−1
Pearson’s correlation: R = 0.67 ()
Bland–Altman: LOA (−1610,607 kJ·d−1)
TriTrac-R3D:
Data available for 12 subjects
Mean difference: −401.7 kJ·d−1
Pearson’s correlation: R = 0.36 ()
Bland–Altman: LOA (−3711; 2469 kJ·d−1)
RT3 provides more accurate estimations than TriTrac-R3D. RT3 is a valuable instrument for the evaluation of AEE at group level, but there is a need to compensate for the underestimation in free-living conditions. At individual level, both the accelerometers present some limitations

[39]TracmorD triaxial accelerometer system (Maastricht, the Netherlands)DLWTEE, PAL calculated as TEE divided by SMR (measured by an overnight state in a respiration chamber), AEE calculated as (0.9 × TEE) −SMR, AEEkg calculated as AEE/BMI. Prediction equations for TracmorD : AEE = 24.113 × MCounts/day + 8.5231 PAL = 0.3218 × MCounts/day + 1.2766PAL and AEE measured from TracmorD and DLW47% of the variance of PAL and 58% of the variance of AEEkg were explained by the prediction equations Bias AEEkg = 17%; PAL = −1%Two published equations derived with TracmorD allow valid assessment of physical activity in overweight and obese subjects

AEE: activity energy expenditure; DLW: doubly labelled water; EE: energy expenditure; EP: early uninterrupted phase of sleep; IC: indirect calorimetry; LP = late uninterrupted phase of sleep; PA: physical activity; PAL: physical activity level; REE: resting energy expenditure; RMR: resting metabolic rate; SEE: sleep energy expenditure; SIT: sitting; SMR: sleeping metabolic rate; STAND: standing; SWA: SenseWear Armband; TEE: total energy expenditure; VO2 max: maximal oxygen uptake.