Adult Patients Affected by Cystic Fibrosis in Therapy with Cystic Fibrosis Transmembrane Regulator Modulators and Lung Transplant: Renal Function, Metabolic and Nutritional Status
Table 3
Patients’ characteristics at T0 and T1.
Group 0 at T0 N = 29
Group 0 at T1
value
Group 1 at T0 N = 19
Group 1 at T1
value
Group 2 at T0 N = 21
Group 2 at T1
value
Age
35.01 ± 10.57
—
—
32.47 ± 9.40
—
—
38.93 ± 7.14
—
—
Creatinine (mg/dL)
0.75 ± 0.14
0.78 ± 0.4
0.709
0.76 ± 0.11
0.76 ± 0.16
1
0.83 ± 0.10
1.16 ± 0.34
<0.001
eGFR (ml/min)
110.0 ± 25.26
107.66 ± 25.01
0.746
107.60 ± 13.98
113.0 ± 22.38
0.378
103.46 ± 22.42
69.38 ± 20.93
<0.001
Serum nitrogen (mg/dL)
5.17 ± 1.42
5.21 ± 1.49
0.923
5.48 ± 1.19
5.52 ± 1.21
0.918
5.26 ± 1.01
9.64 ± 3.34
<0.001
Serum uric acid (mmol/L)
0.32 ± 0.07
0.32 ± 0.06
1
0.33 ± 0.06
0.34 ± 0.07
0.639
0.37 ± 0.09
0.43 ± 0.10
0.047
Serum sodium (mEq/L)
140.33 ± 3.23
141.14 ± 3.21
0.384
141.33 ± 2.11
140.53 ± 1.93
0.939
140.73 ± 2.32
143.62 ± 2.65
<0.001
Serum potassium (mEq/L)
4.56 ± 0.40
4.58 ± 0.32
0.850
4.43 ± 0.29
4.46 ± 0.27
0.743
4.58 ± 0.40
3.94 ± 0.52
<0.001
Total protein (g/dL)
7.67 ± 0.30
78.52 ± 6.21
0.175
7.73 ± 0.44
75.58 ± 5.13
0.274
7.63 ± 0.51
6.72 ± 0.41
<0.001
Serum albumin (g/dL)
4.51 ± 0.35
44.55 ± 4.44
0.595
4.46 ± 0.25
46.26 ± 4.62
0.176
4.42 ± 0.19
4.2 ± 0.34
0.013
Serum fibrinogen (g/L)
3.31 ± 0.53
3.52 ± 0.84
0.284
3.49 ± 0.74
3.17 ± 0.78
0.202
3.33 ± 0.85
2.93 ± 0.75
0.113
Serum transferrin (g/L)
2.83 ± 0.48
2.53 ± 0.36
0.019
3.08 ± 0.60
3.16 ± 0.64
0.693
2.80 ± 0.37
2.52 ± 0.61
0.079
White blood cells, ×10³ (cells/µL)
8.16 ± 3.23
8.58 ± 2.66
0.628
7.34 ± 1.74
6.50 ± 1.58
0.128
7.86 ± 2.08
7.85 ± 1.76
0.986
HbA1c (%)
5.53 ± 0.45
5.74 ± 0.73
0.215
5.86 ± 1.01
5.98 ± 0.85
0.694
5.38 ± 0.51
6.54 ± 1.19
<0.001
CRP (mcg/L)
3 (82–1600)
400 (120–8000)
0.009
2000 (812–8425)
455 (177.5–2350)
0.017
1020 (400–3400)
1300 (700–2750)
0.415
NLR
2.39 ± 1.34
2.89 ± 4.34
0.471
2.37 ± 1.08
2.44 ± 0.85
0.825
2.15 ± 0.98
2.70 ± 1.43
0.153
Neutrophils (×10³)
4345.0 ± 1657.09
6197.8 ± 1080.0
<0.001
4493.0 ± 1736.34
5070.52 ± 1920.0
0.337
4696.0 ± 1740.20
5897.6 ± 1900.0
0.003
CF, cystic fibrosis, CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; HbA1c, A1c haemoglobin; N, number of patients; NLR, neutrophil-to-lymphocyte ratio. Data are shown as mean ± standard deviation or number (%). Group 0: CF patients on conservative therapy (controls); group 1: CF patients with CFTR modulator therapy; group 2: lung transplant recipient patients.
